Skip to content

Study · Animal study (in vivo) · rat · 2015

4 results

Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats.

Surampudi P, Chang I, Lue Y, Doumit T, Jia Y, Atienza V, Liu PY, Swerdloff RS, Wang C

Andrology16 Apr 2015Cited by 22 (Europe PMC)

PMID25891800 (opens in a new tab)PMCIDPMC5034733 (opens in a new tab)DOI10.1111/andr.12036 (opens in a new tab)PepBankPUB-25891800
Source linkPubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats, humanin plus cyclophosphamide significantly reduced cyclophosphamide-induced germ cell apoptosis at early and late stages of the seminiferous epithelial cycle.

    In plain wordsIn rats, humanin reduced germ cell death caused by cyclophosphamide at early and late stages of the sperm-forming cycle.

    Peptide
    Humanin
    Outcome
    DecreaseCyclophosphamide-induced germ cell apoptosis at early and late stages of the seminiferous epithelial cycle
    Study

    ratn: not reported in source

    Comparator
    Cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN +CP significantly reduced CP-induced apoptosis at early (I-VI) and late stages (IX-XIV)
    1 context sentence
    Summary · context
    To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP); or (iv) HN+CP.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In adult rats, humanin did not reduce cyclophosphamide-induced germ cell apoptosis at the middle stages (VII-VIII) of the seminiferous epithelial cycle.

    In plain wordsIn rats, humanin did not reduce germ cell death caused by cyclophosphamide at the middle stages of the sperm-forming cycle.

    Peptide
    Humanin
    Outcome
    No significant changeCyclophosphamide-induced germ cell apoptosis at middle stages of the seminiferous epithelial cycle
    Study

    ratn: not reported in source

    Comparator
    Cyclophosphamide alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN +CP significantly reduced CP-induced apoptosis at early (I-VI) and late stages (IX-XIV) but not at middle stages (VII-VIII) of the seminiferous epithelial cycle.
    1 context sentence
    Summary · context
    To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP); or (iv) HN+CP.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats whose Leydig cells were depleted with EDS, humanin significantly attenuated germ cell apoptosis at the middle stages.

    In plain wordsIn rats without Leydig cells, humanin reduced germ cell death at the middle stages of the sperm-forming cycle.

    Peptide
    Humanin
    Outcome
    DecreaseGerm cell apoptosis at middle stages in rats pre-treated with EDS
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN significantly attenuated germ cell apoptosis at the middle stages in EDS pre-treated rats.
    2 context sentences
    Summary · context
    Pre-treatment with EDS markedly suppressed serum and intratesticular testosterone (T) levels, and significantly increased germ cell apoptosis at the middle (VII-VIII) stages.
    Summary · context
    To examine whether HN has protective effects on chemotherapy-induced male germ cell apoptosis, we treated four groups of adult rats with (i) vehicle (control), (ii) HN, (iii) cyclophosphamide (CP); or (iv) HN+CP.
  4. 04LabIn vitro (cells)Efficacy outcome

    In isolated adult Leydig cells, humanin did not prevent the reduction of testosterone production caused by ketoconazole.

    In plain wordsIn cells, humanin did not prevent the drop in testosterone production caused by ketoconazole.

    Peptide
    Humanin
    Outcome
    No significant changeTestosterone production reduced by ketoconazole
    Study

    ratn: not reported in source

    isolated adult Leydig cells treated with ketoconazole
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    To investigate whether HN has any direct effects on Leydig cell function, adult Leydig cells were isolated and treated with ketoconazole (KTZ) to block testosterone synthesis.
    1 context sentence
    Summary · context
    HN was not effective in preventing the reduction of T production by KTZ in vitro.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.