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Study · Not a test of the peptide alone · 2015

3 results

Two functionally distinct sources of actin monomers supply the leading edge of lamellipodia.

Vitriol EA, McMillen LM, Kapustina M, Gomez SM, Vavylonis D, Zheng JQ

Cell reports10 Apr 2015Cited by 80 (Europe PMC)

PMID25865895 (opens in a new tab)PMCIDPMC4418508 (opens in a new tab)DOI10.1016/j.celrep.2015.03.033 (opens in a new tab)PepBankPUB-25865895
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In motile cells, cytosolic G-actin needed the monomer-binding protein Tβ4 for optimal leading-edge localization and for an elevated G/F-actin ratio that promotes membrane protrusion.

    In plain wordsIn cells, the cell's own Tβ4 helped actin building blocks reach the front edge of the cell.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4 requirement for G-actin leading-edge localization
    Study

    n: not reported in source

    motile cells, lamellipodia
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    G-actin originating from the cytosolic pool requires the monomer-binding protein thymosin β4 (Tβ4) for optimal leading-edge localization, is targeted to formins, and is responsible for creating an elevated G/F-actin ratio that promotes membrane protrusion.
    1 context sentence
    Summary · context
    Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and disassembly into actin monomers (G-actin).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In motile cells, recycling of lamellipodia F-actin into the second G-actin source occurred independently of Tβ4.

    In plain wordsIn cells, recycling of actin from the cell front did not depend on the cell's own Tβ4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableTβ4 independence of F-actin recycling
    Study

    n: not reported in source

    motile cells, lamellipodia
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    Recycling occurs independently of Tβ4 and appears to regulate lamellipodia homeostasis.
    1 context sentence
    Summary · context
    Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and disassembly into actin monomers (G-actin).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In motile cells, Tβ4-bound G-actin localized specifically to the leading edge because it did not interact with Arp2/3-mediated polymerization sites.

    In plain wordsIn cells, actin bound to the cell's own Tβ4 went to the front edge and did not join Arp2/3 sites.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableLeading-edge localization of Tβ4-bound G-actin
    Study

    n: not reported in source

    motile cells, lamellipodia
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    Tβ4-bound G-actin specifically localizes to the leading edge because it does not interact with Arp2/3-mediated polymerization sites found throughout the lamellipodia.
    1 context sentence
    Summary · context
    Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and disassembly into actin monomers (G-actin).

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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