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Study · Animal study (in vivo) · rat · 2015

2 results

Humanin Does Not Protect Against STZ-Induced Spatial Memory Impairment.

Negintaji K, Zarifkar A, Ghasemi R, Moosavi M

Journal of molecular neuroscience : MN6 Mar 2015Cited by 2 (Europe PMC)

PMID25744099 (opens in a new tab)DOI10.1007/s12031-015-0531-8 (opens in a new tab)PepBankPUB-25744099
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with STZ-induced spatial memory impairment, humanin at 0.01 to 1 nmol did not restore the memory deficit.

    In plain wordsIn rats with a memory problem caused by streptozotocin, humanin did not restore memory at any dose tested.

    Peptide
    Humanin
    Outcome
    No significant changeRestoration of STZ-induced spatial memory deficit (Morris water maze)
    Study

    ratn: not reported in source

    intracerebroventricular STZ model of sporadic Alzheimer's disease
    Comparator
    Saline
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    0.01, 0.05, 0.1 and 1 nmol · from day 4 to day 14As given in this study (rat).

    Source sentences

    Summary
    The results showed that STZ significantly impaired spatial memory, and humanin in a wide range of doses (0.01, 0.05, 0.1, and 1 nmol) failed to restore STZ-induced deficit.
    2 context sentences
    Summary · context
    Adult male Sprague-Dawely rats weighting 250-300 g were used, and cannuls were implanted bilaterally into lateral ventricles.
    Summary · context
    STZ was administered on days 1 and 3 (3 mg/kg), and humanin (0.01, 0.05, 0.1, and 1 nmol) or saline were injected from day 4 and continued till day 14.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats given STZ, humanin did not restore the disrupted level of phosphorylated Akt in the hippocampus.

    In plain wordsIn rats given streptozotocin, humanin did not restore a disrupted brain signal (phosphorylated Akt).

    Peptide
    Humanin
    Outcome
    No significant changeRestoration of hippocampal phosphorylated Akt after STZ
    Study

    ratn: not reported in source

    intracerebroventricular STZ model of sporadic Alzheimer's disease
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated · from day 4 to day 14As given in this study (rat).

    Source sentences

    Summary
    It was also revealed that humanin was not efficient in restoring pAkt disruption.
    2 context sentences
    Summary · context
    Adult male Sprague-Dawely rats weighting 250-300 g were used, and cannuls were implanted bilaterally into lateral ventricles.
    Summary · context
    STZ was administered on days 1 and 3 (3 mg/kg), and humanin (0.01, 0.05, 0.1, and 1 nmol) or saline were injected from day 4 and continued till day 14.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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