Study · Animal study (in vivo) · mouse · 2015
6 resultsLee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, Kim SJ, Mehta H, Hevener AL, de Cabo R, de Cabo R, Cohen P
Cell metabolism1 Mar 2015Cited by 584 (Europe PMC)
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Text rights: Publisher copyright. Results still quote short attributed sentences.
6 results from studies that gave the peptide. No result from this study comes from people.
In mice, MOTS‑c treatment prevented age-dependent insulin resistance.
In plain wordsIn mice, MOTS‑c treatment prevented insulin resistance that comes with age.
mousen: not reported in source
Aged miceSource sentences
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
In mice, MOTS‑c treatment prevented high-fat-diet-induced insulin resistance.
In plain wordsIn mice, MOTS‑c treatment prevented insulin resistance caused by a high-fat diet.
mousen: not reported in source
High-fat-diet miceSource sentences
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
In mice, MOTS‑c treatment prevented diet-induced obesity.
In plain wordsIn mice, MOTS‑c treatment prevented weight gain from a high-fat diet.
mousen: not reported in source
High-fat-diet miceSource sentences
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity.
In cells, MOTS‑c actions inhibited the folate cycle.
In plain wordsIn cells, MOTS‑c reduced the activity of the folate cycle.
n: not reported in source
CellsSource sentences
Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation.
In cells, MOTS‑c actions inhibited de novo purine biosynthesis tethered to the folate cycle.
In plain wordsIn cells, MOTS‑c reduced the making of purines, building blocks of DNA.
n: not reported in source
CellsSource sentences
Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation.
In cells, MOTS‑c actions led to AMPK activation.
In plain wordsIn cells, MOTS‑c switched on the enzyme AMPK.
n: not reported in source
CellsSource sentences
Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation.
AI wrote and checked these results. AI can make mistakes, so check important results against the source.
PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.
Versions 4 to 18Current
28 Oct 2026, 02:02 UTC
The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.
Study results updated
Version 3
13 Oct 2026, 16:31 UTC
Study data updated · source update from Europe PMC
Version 2
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC
Terms as the source lists them.
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