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Study · Animal study (in vivo) · mouse · 2015

3 results

The effect of Kisspeptin-10 on mesenchymal stem cells migration in vitro and in vivo.

Golzar F, Javanmard SH, Bahrambeigi V, Rafiee L

Advanced biomedical research30 Jan 2015Cited by 3 (Europe PMC)

PMID25709985 (opens in a new tab)PMCIDPMC4333426 (opens in a new tab)DOI10.4103/2277-9175.149851 (opens in a new tab)PepBankPUB-25709985
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In melanoma-bearing mice, MSCs treated with kisspeptin‑10 migrated more at 100 nM and less at 500 nM.

    In plain wordsIn mice with melanoma, stem cells treated with a lower kisspeptin‑10 dose moved more and with a higher dose moved less.

    Peptide
    Kisspeptin-10
    Outcome
    MixedMSC migration to tumors in vivo
    Study

    mousen: not reported in source

    C57BL/6 mice bearing melanoma tumors, given kp-10-treated labeled adipose-derived MSCs
    Comparator
    Untreated cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    10-100 or 500 nMAs given in this study (mouse).

    Source sentences

    Summary
    We have found that kp-10 increased the MSCs migration at 100 nM, while it decreased the MSCs migration at 500 nM, both in vitro and in vivo
    2 context sentences
    Summary · context
    We compared the directional migration of MSCs treated with 10-100 or 500 nM kp-10 for 24 hours and no treated cells using an in vitro transmembrane migration assay.
    Summary · context
    In addition, Chloromethylbenzamido Dialkylacarbocyanine (CM-Dil) labeled adipose-derived mesenchymal stem cells treated with 10-100 or 500 nM kp-10 and no treated cells were transfused via the tail vein to the melanoma tumor bearing C57BL/6 mice.
  2. 02LabIn vitro (cells)Efficacy outcome

    In vitro, kisspeptin‑10 increased mesenchymal stem cell migration at 100 nM and decreased it at 500 nM.

    In plain wordsIn lab tests, a lower kisspeptin‑10 dose raised stem cell movement and a higher dose lowered it.

    Peptide
    Kisspeptin-10
    Outcome
    MixedMSC migration in vitro
    Study

    n: not reported in source

    mesenchymal stem cells (MSCs)
    Comparator
    Untreated cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    10-100 or 500 nM · 24 hoursAs given in this study.

    Source sentences

    Summary
    We have found that kp-10 increased the MSCs migration at 100 nM, while it decreased the MSCs migration at 500 nM, both in vitro and in vivo
    2 context sentences
    Summary · context
    We compared the directional migration of MSCs treated with 10-100 or 500 nM kp-10 for 24 hours and no treated cells using an in vitro transmembrane migration assay.
    Summary · context
    In addition, Chloromethylbenzamido Dialkylacarbocyanine (CM-Dil) labeled adipose-derived mesenchymal stem cells treated with 10-100 or 500 nM kp-10 and no treated cells were transfused via the tail vein to the melanoma tumor bearing C57BL/6 mice.
  3. 03LabIn vitro (cells)Mechanism

    Kisspeptin‑10 at 100 nM significantly increased CXCR4 expression in mesenchymal stem cells compared with untreated cells.

    In plain wordsIn lab tests, kisspeptin‑10 at 100 nM raised CXCR4 levels in stem cells compared with untreated cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCXCR4 expression at 100 nM
    Study

    n: not reported in source

    mesenchymal stem cells (MSCs)
    Comparator
    Untreated cells
    Outcome group
    Receptor activity and mechanism · Cancer
    Studied dose
    10-100 or 500 nMAs given in this study.

    Source sentences

    Summary
    with a significant increase of CXCR4 expression at 100 nM kp-10 compared to the no treated cells, but it had no significant difference between the various concentrations of kp-10.
    2 context sentences
    Summary · context
    We compared the directional migration of MSCs treated with 10-100 or 500 nM kp-10 for 24 hours and no treated cells using an in vitro transmembrane migration assay.
    Summary · context
    In addition, Chloromethylbenzamido Dialkylacarbocyanine (CM-Dil) labeled adipose-derived mesenchymal stem cells treated with 10-100 or 500 nM kp-10 and no treated cells were transfused via the tail vein to the melanoma tumor bearing C57BL/6 mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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