Radiolabeled TFIB tagged the tumor-targeting peptides PEG3[c(RGDyK)]2 and NDP-MSH in mild conditions with radiochemical yields of 47-83% and purities above 99%.
In plain wordsIn lab chemistry, a new radiolabel was attached to two tumor-targeting peptides, including NDP-MSH, with good yields and high purity.
- Peptide
- Melanotan I (afamelanotide)
- Outcome
- Not applicableRadiolabeling yield and purity of TFIB-tagged peptides
- Study
n: not reported in source
Radiochemical synthesis- Outcome group
- Synthesis and manufacturing · Pharmacology
Measurements
- Radiochemical yield
- 47 to 83 % d.c.
- TFIB-tagged peptides
- Radiochemical purity
- > 99%
- TFIB-tagged peptides
Source sentences
Then, radiolabeled [ (125) I]/[ (18) F]TFIB was used to tag tumor-targeting peptides (i.e., PEG3[c(RGDyK)]2 and NDP-MSH targeting αvβ3 integrin and MC1R receptors, respectively) in mild conditions and with good radiochemical yields (47-83% d.c.) and purities (>99%).
In this study, Melanotan I (afamelanotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Melanotan I (afamelanotide).