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Study · Animal study (in vivo) · mouse · 2015

8 results

The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs.

Jia Y, Ohanyan A, Lue YH, Swerdloff RS, Liu PY, Cohen P, Wang C

Apoptosis : an international journal on programmed cell death1 Apr 2015Cited by 40 (Europe PMC)

PMID25666707 (opens in a new tab)PMCIDPMC4351164 (opens in a new tab)DOI10.1007/s10495-015-1105-5 (opens in a new tab)PepBankPUB-25666707
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, humanin decreased cyclophosphamide-induced male germ cell apoptosis in the testis.

    In plain wordsIn mice, humanin reduced testis germ cell death caused by the chemotherapy drug cyclophosphamide.

    Peptide
    Humanin
    Outcome
    DecreaseCyclophosphamide-induced male germ cell apoptosis (in vivo)
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study we showed that HN ameliorated chemotherapy [cyclophosphamide (CP) and Doxorubicin (DOX)]-induced male germ cell apoptosis both ex vivo in seminiferous tubule cultures and in vivo in the testis.
    2 context sentences
    Summary · context
    decreases DOX (ex vivo) and CP (in vivo) induced male germ cell apoptosis
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In mice, humanin restored cyclophosphamide-suppressed STAT3 phosphorylation.

    In plain wordsIn mice, humanin restored a cell signal (STAT3 phosphorylation) that cyclophosphamide had lowered.

    Peptide
    Humanin
    Outcome
    IncreaseSTAT3 phosphorylation suppressed by cyclophosphamide
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN, HN-S7A, and HN-C8P restored CP-suppressed STAT3 phosphorylation.
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.
  3. 03LabEx vivo tissueEfficacy outcome

    In seminiferous tubule cultures, humanin decreased doxorubicin-induced male germ cell apoptosis.

    In plain wordsIn lab tests on testis tissue, humanin reduced germ cell death caused by the chemotherapy drug doxorubicin.

    Peptide
    Humanin
    Outcome
    DecreaseDoxorubicin-induced male germ cell apoptosis (ex vivo)
    Study

    n: not reported in source

    seminiferous tubule cultures
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In this study we showed that HN ameliorated chemotherapy [cyclophosphamide (CP) and Doxorubicin (DOX)]-induced male germ cell apoptosis both ex vivo in seminiferous tubule cultures and in vivo in the testis.
    2 context sentences
    Summary · context
    decreases DOX (ex vivo) and CP (in vivo) induced male germ cell apoptosis
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

Studies that did not test the peptide alone5

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice, the humanin analogues HNG, HNG-F6A, HN-S7A and HN-C8P (less effective) inhibited cyclophosphamide-induced male germ cell apoptosis.

    In plain wordsIn mice, four humanin analogues reduced germ cell death caused by cyclophosphamide.

    Peptide
    Humanin
    Outcome
    DecreaseCyclophosphamide-induced germ cell apoptosis, HNG, HNG-F6A, HN-S7A and HN-C8P
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    CP-induced germ cell apoptosis was inhibited by HN, HNG, HNG-F6A, HN-S7A, and HN-C8P (less effective); but not by HN-L12A.
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice, the humanin antagonist analogue HN-L12A did not inhibit cyclophosphamide-induced male germ cell apoptosis.

    In plain wordsIn mice, the humanin antagonist analogue HN-L12A did not reduce germ cell death caused by cyclophosphamide.

    Peptide
    Humanin
    Outcome
    No significant changeCyclophosphamide-induced germ cell apoptosis, HN-L12A
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    CP-induced germ cell apoptosis was inhibited by HN, HNG, HNG-F6A, HN-S7A, and HN-C8P (less effective); but not by HN-L12A.
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 06AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice, the antagonist analogue HN-L12A blocked the protective effect of humanin against cyclophosphamide-induced male germ cell apoptosis.

    In plain wordsIn mice, the antagonist analogue HN-L12A blocked the protection that humanin gave against germ cell death.

    Peptide
    Humanin
    Outcome
    IncreaseBlock of the humanin protective effect by HN-L12A
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    HN-L12A, but not HN-S7A or HN-C8P, blocked the protective effect of HN against CP-induced male germ cell apoptosis
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 07AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In mice, the analogues HN-S7A and HN-C8P did not block the protective effect of humanin against cyclophosphamide-induced male germ cell apoptosis.

    In plain wordsIn mice, the analogues HN-S7A and HN-C8P did not block the protection that humanin gave against germ cell death.

    Peptide
    Humanin
    Outcome
    No significant changeBlock of the humanin protective effect by HN-S7A or HN-C8P
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    HN-L12A, but not HN-S7A or HN-C8P, blocked the protective effect of HN against CP-induced male germ cell apoptosis.
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 08AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In mice, the humanin analogues HN-S7A and HN-C8P restored cyclophosphamide-suppressed STAT3 phosphorylation.

    In plain wordsIn mice, two humanin analogues restored a cell signal (STAT3 phosphorylation) that cyclophosphamide had lowered.

    Peptide
    Humanin
    Outcome
    IncreaseSTAT3 phosphorylation suppressed by cyclophosphamide, HN-S7A and HN-C8P
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    HN, HN-S7A, and HN-C8P restored CP-suppressed STAT3 phosphorylation.
    1 context sentence
    Summary · context
    To understand the mechanisms of HN on male germ cell apoptosis, we studied five HN analogues including: HNG (HN-S14G, a potent agonist), HNG-F6A (no binding to IGFBP-3), HN-S7A (no self-dimerization), HN-C8P (no binding to BAX), and HN-L12A (a HN antagonist) on CP-induced male germ cell apoptosis in mice.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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