Actin cytoskeletal rearrangement and dysfunction due to activation of the receptor for advanced glycation end products is inhibited by thymosin beta 4.

Kim S, Kwon J

The Journal of physiology27 Feb 2015Cited by 13 (Europe PMC)

PMID25640761DOI10.1113/jphysiol.2014.287045PepBankPUB-25640761

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In HUVECs incubated with AGEs, Tβ4 increased cell viability.
In plain wordsIn cells exposed to AGEs, Tβ4 increased cell survival.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell viability with AGEs
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 increased cell viability
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
Report a problemFND-2564076101
02LabIn vitro (cells)Mechanism
In HUVECs incubated with AGEs, Tβ4 decreased levels of reactive oxygen species.
In plain wordsIn cells exposed to AGEs, Tβ4 lowered reactive oxygen species.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseReactive oxygen species with AGEs
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 increased cell viability and decreased levels of reactive oxygen species in HUVECs incubated with AGEs.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
Report a problemFND-2564076102
03LabIn vitro (cells)Mechanism
In HUVECs, Tβ4 reduced the expression of RAGE.
In plain wordsIn cells, Tβ4 lowered the amount of the AGE receptor RAGE.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseRAGE expression
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Tβ4 reduced the expression of RAGE, consistent with a down-regulation of the F-actin to G-actin ratio.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
Report a problemFND-2564076103
04LabIn vitro (cells)Mechanism
In HUVECs, Tβ4 reduced RAGE expression, consistent with a down-regulation of the F-actin to G-actin ratio.
In plain wordsIn cells, Tβ4 lowered the ratio of filamentous to globular actin.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseF-actin to G-actin ratio
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
consistent with a down-regulation of the F-actin to G-actin ratio.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
Report a problemFND-2564076104
05LabIn vitro (cells)Mechanism
In HUVECs, Tβ4 reversed the reduction of vascular-like tube formation caused by AGEs.
In plain wordsIn cells, Tβ4 reversed the loss of tube formation caused by AGEs.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseVascular-like tube formation with AGEs
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
AGEs attenuate vascular-like tube formation of HUVECs, which is reversed by Tβ4 via remodelling of the actin cytoskeleton.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
Report a problemFND-2564076105

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In HUVECs, siRNA removal of the body's own Tβ4 increased RAGE expression.
In plain wordsIn cells, removing the cells' own Tβ4 raised the amount of the AGE receptor RAGE.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseRAGE expression after loss of intrinsic Tβ4
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
The absence of intrinsic Tβ4 in HUVECs evoked actin cytoskeleton disorder and increased RAGE expression.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2564076106
07LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism
In HUVECs, siRNA removal of the body's own Tβ4 caused actin cytoskeleton disorder.
In plain wordsIn cells, removing the cells' own Tβ4 disordered the actin cytoskeleton.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseActin cytoskeleton disorder after loss of intrinsic Tβ4
Study
humann: not reported in source
HUVECs incubated with AGEs
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
evoked actin cytoskeleton disorder and increased RAGE expression.
2 context sentences(design, population, supporting numbers)
Summary · context
Moreover, small interfering RNA was used to determine whether intrinsic Tβ4 regulates RAGE expression in the actin cytoskeleton.
Summary · context
In this study we examined the role of thymosin beta 4 (Tβ4 ) - which binds to actin, blocks actin polymerization, and maintains the dynamic equilibrium between G-actin and F-actin in human umbilical vein endothelial cells (HUVECs) - in the response to RAGE.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2564076107

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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