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Study · Measured the body's own peptide · 2015

8 results

The effect of sex on humanin levels in healthy adults and patients with uncomplicated type 1 diabetes mellitus.

Lytvyn Y, Wan J, Lai V, Cohen P, Cherney DZ

Canadian journal of physiology and pharmacology18 Dec 2014Cited by 8 (Europe PMC)

PMID25615723 (opens in a new tab)DOI10.1139/cjpp-2014-0401 (opens in a new tab)PepBankPUB-25615723
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Natural levels measured8

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In adults with uncomplicated type 1 diabetes, natural plasma humanin levels were higher in men than in women.

    In plain wordsIn adults with type 1 diabetes, men had higher levels of the body's own humanin than women.

    Peptide
    Humanin
    Outcome
    IncreasePlasma humanin, type 1 diabetes men versus type 1 diabetes women
    Study

    n = 41

    Comparator
    Women with type 1 diabetes
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    levels in the T1D men were higher compared with the T1D women (p = 0.026)
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Natural plasma humanin levels were higher in men with uncomplicated type 1 diabetes than in healthy men.

    In plain wordsMen with type 1 diabetes had higher levels of the body's own humanin than healthy men.

    Peptide
    Humanin
    Outcome
    IncreasePlasma humanin, type 1 diabetes men versus healthy men
    Study

    n = 34

    Comparator
    Healthy men
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In contrast, levels in the T1D men were higher compared with the T1D women (p = 0.026) and HC men (p < 0.0001).
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In men with uncomplicated type 1 diabetes, natural plasma humanin correlated negatively with plasma cGMP.

    In plain wordsIn men with type 1 diabetes, higher levels of the body's own humanin were linked to lower cGMP.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of humanin with plasma cGMP in type 1 diabetes men
    Study

    n = 23

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In the T1D men, HN negatively correlated with plasma cGMP.
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In healthy adults, natural plasma humanin levels tended to be lower in men than in women, but the difference was not statistically significant.

    In plain wordsIn healthy adults, the body's own humanin levels were not clearly different between men and women.

    Peptide
    Humanin
    Outcome
    No significant changePlasma humanin, healthy men versus healthy women
    Study

    n = 21

    Comparator
    Healthy women
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Plasma HN levels were generally lower in HC men by comparison with the women, but the differences were not statistically significant.
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In women with uncomplicated type 1 diabetes, natural plasma humanin did not correlate with neurohormones or vascular function.

    In plain wordsIn women with type 1 diabetes, the body's own humanin was not linked to neurohormones or vascular function.

    Peptide
    Humanin
    Outcome
    No significant changeCorrelation of humanin with neurohormones and vascular function in type 1 diabetes women
    Study

    n = 18

    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In the T1D women, HN did not correlate with neurohormones or vascular function.
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In healthy men, natural plasma humanin correlated negatively with blood pressure.

    In plain wordsIn healthy men, higher levels of the body's own humanin were linked to lower blood pressure.

    Peptide
    Humanin
    Outcome
    DecreaseCorrelation of humanin with blood pressure in healthy men
    Study

    n = 11

    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    In the HC men, but not the women, HN correlated negatively with BP
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  7. 07HumanEndogenous levelObservational studyOther

    In healthy men, natural plasma humanin did not correlate with renal function, cGMP or aldosterone.

    In plain wordsIn healthy men, the body's own humanin was not linked to kidney function, cGMP or aldosterone.

    Peptide
    Humanin
    Outcome
    No significant changeCorrelation of humanin with renal function, cGMP and aldosterone in healthy men
    Study

    n = 11

    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    but not with renal function, cGMP, or aldosterone.
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  8. 08HumanEndogenous levelObservational studyOther

    In healthy women, natural plasma humanin did not correlate with blood pressure.

    In plain wordsIn healthy women, the body's own humanin was not linked to blood pressure.

    Peptide
    Humanin
    Outcome
    No significant changeCorrelation of humanin with blood pressure in healthy women
    Study

    n = 10

    Outcome group
    Blood pressure · Cardiovascular

    Source sentences

    Summary
    In the HC men, but not the women, HN correlated negatively with BP, but not with renal function, cGMP, or aldosterone.
    1 context sentence
    Summary · context
    Plasma HN, cGMP and aldosterone, blood pressure (BP), glomerular filtration rate, and effective renal plasma flow (inulin and para-aminohippurate) were measured in HC (11 men, 10 women) and T1D (23 men and 18 women) during clamped euglycemia (4-6 mmol·L(-1)).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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