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Study · Not a test of the peptide alone · 2015

4 results

Toward oral delivery of biopharmaceuticals: an assessment of the gastrointestinal stability of 17 peptide drugs.

Wang J, Yadav V, Smart AL, Tajiri S, Basit AW

Molecular pharmaceutics10 Feb 2015Cited by 193 (Europe PMC)

PMID25612507 (opens in a new tab)DOI10.1021/mp500809f (opens in a new tab)PepBankPUB-25612507
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01LabNot a test of Goserelin aloneIn vitro (cell-free)Activity measurement

    In lab tests, goserelin degraded rapidly in human small intestinal fluid.

    In plain wordsIn lab tests, goserelin degraded rapidly in human small intestinal fluid.

    Peptide
    Goserelin
    Outcome
    Direction not reportedSmall intestinal degradation
    Study

    n: not reported in source

    Human small intestinal fluid
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In human small intestinal fluid, however, both small and large peptides degraded rapidly with the exception of the cyclic peptide ciclosporin and the disulfide-bridge containing peptides octreotide and desmopressin, which showed good stability.

    In this study, Goserelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Goserelin.

  2. 02LabNot a test of Histrelin aloneIn vitro (cell-free)Activity measurement

    In lab tests, histrelin degraded rapidly in human small intestinal fluid.

    In plain wordsIn lab tests, histrelin degraded rapidly in human small intestinal fluid.

    Peptide
    Histrelin
    Outcome
    Direction not reportedSmall intestinal degradation
    Study

    n: not reported in source

    Human small intestinal fluid
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In human small intestinal fluid, however, both small and large peptides degraded rapidly with the exception of the cyclic peptide ciclosporin and the disulfide-bridge containing peptides octreotide and desmopressin, which showed good stability.

    In this study, Histrelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Histrelin.

  3. 03LabNot a test of Nafarelin aloneIn vitro (cell-free)Activity measurement

    In lab tests, nafarelin degraded rapidly in human small intestinal fluid.

    In plain wordsIn lab tests, nafarelin degraded rapidly in human small intestinal fluid.

    Peptide
    Nafarelin
    Outcome
    Direction not reportedSmall intestinal degradation
    Study

    n: not reported in source

    Human small intestinal fluid
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In human small intestinal fluid, however, both small and large peptides degraded rapidly with the exception of the cyclic peptide ciclosporin and the disulfide-bridge containing peptides octreotide and desmopressin, which showed good stability.

    In this study, Nafarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Nafarelin.

  4. 04LabNot a test of Oxytocin aloneIn vitro (cell-free)Activity measurement

    In lab tests, oxytocin degraded rapidly in human small intestinal fluid.

    In plain wordsIn lab tests, oxytocin degraded rapidly in human small intestinal fluid.

    Peptide
    Oxytocin
    Outcome
    Direction not reportedSmall intestinal degradation
    Study

    n: not reported in source

    Human small intestinal fluid
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    In human small intestinal fluid, however, both small and large peptides degraded rapidly with the exception of the cyclic peptide ciclosporin and the disulfide-bridge containing peptides octreotide and desmopressin, which showed good stability.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 5Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Versions 2 to 4

    27 Oct 2026, 16:36 UTC

    The same notice was added 3 times, first on 27 Oct 2026, 16:35 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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