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Study · Animal study (in vivo) · goat · 2014

1 result

Luteal activity of Abadeh ecotype does in summer and winter and the effect of kisspeptin-10 on luteinizing hormone secretion in the anestrus does.

Arjmand M, Mirzaei A, Jafarzadeh Shirazi MR, Tamadon A, Salehi MS, Saeb M, Namavar MR, Zandi MR, Shahheidari H, Moradi S

Veterinary research forum : an international quarterly journal1 Jan 2014Cited by 4 (Europe PMC)

PMID25610575 (opens in a new tab)PMCIDPMC4299989 (opens in a new tab)PepBankPUB-25610575
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Summary

The aims of the present study were to evaluate luteal activity in Abadeh ecotype goat during summer and winter and also the effect of a single dose kisspeptin-10 injection on the secretion of luteinizing hormone (LH) in female anestrous goats. In the first study, progesterone (P4) concentration in 10 goats in summer (n = 6) and winter (n = 4) were measured every other day. Moreover, in summer group, a male teaser goat was left in the herd on days of sampling for one hour. Goats with P4 concentration ≥1 ng mL(-1), at least two consecutive measurements, were considered with luteal activity. In the second study, the anestrous phase was confirmed by P4 measurement 20 and 10 days before the kisspeptin injection in five female Abadeh ecotype goats (4 to 5 years old). The goats were given a single IV injection of saline (2 mL) as control group and the same goats (1 hr after the last blood sampling) were given kisspeptin (1 μg kg(-1)) as treatment group. The blood samples were collected at -60, -40, -20 and 0 min (before injection), and 10, 20, 30, 40, 50, 60, 80, 100, 120 and 140 min after the injection and LH concentration were measured. A single IV injection of 1 µg kg(-1) of kisspeptin-10 did not stimulate the release of LH in female anestrous goats. In summer, in the presence of teaser goat, luteal activity was seen in all goats. In the absence of male goat in winter, some goats showed luteal activity and others showed anestrus.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female anestrous goats, a single intravenous dose of kisspeptin‑10 did not stimulate luteinizing hormone release.

    In plain wordsIn female goats outside the breeding season, one injection of kisspeptin‑10 did not raise luteinizing hormone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeLuteinizing hormone release
    Study

    goatn = 5

    Female anestrous Abadeh ecotype goats
    Comparator
    Saline
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    1 µg kg(-1) · intravenous · single doseAs given in this study (goat).

    Source sentences

    Summary
    A single IV injection of 1 µg kg(-1) of kisspeptin-10 did not stimulate the release of LH in female anestrous goats.
    1 context sentence
    Summary · context
    The goats were given a single IV injection of saline (2 mL) as control group and the same goats (1 hr after the last blood sampling) were given kisspeptin (1 μg kg(-1)) as treatment group.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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