Thymosin β4 attenuates microcirculatory and hemodynamic destabilization in sepsis.

Bongiovanni D, Ziegler T, D'Almeida S, Zhang T, Ng JK, Dietzel S, Hinkel R, Kupatt C

Expert opinion on biological therapy21 Jan 2015Cited by 14 (Europe PMC)

PMID25604254DOI10.1517/14712598.2015.1006193PepBankPUB-25604254

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, rAAV.Tβ4 lowered the sepsis severity score at 36 h compared with rAAV.LacZ control.
In plain wordsIn mice with sepsis, a virus that raises Tβ4 gene activity lowered the sepsis severity score at 36 hours versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSepsis severity score at 36 h
Study
mousen: not reported in source
LPS-induced sepsis, rAAV.Tβ4 gene transfer
Comparator
rAAV.LacZ control
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
At 36 h, there was a decrease of sepsis severity score in rAAV.Tβ4-treated animals as compared to rAAV.LacZ-treated control
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
Summary · context
Fourteen days before LPS injection, the mice were injected with an adeno-associated virus carrying the Tβ4 (rAAV.Tβ4) or LacZ gene (rAAV.LacZ).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2560425401
02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, rAAV.Tβ4 lowered perivascular leakage compared with control.
In plain wordsIn mice with sepsis, a virus that raises Tβ4 gene activity lowered blood vessel leakage versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePerivascular leakage
Study
mousen: not reported in source
LPS-induced sepsis, rAAV.Tβ4 gene transfer
Comparator
rAAV.LacZ control
Outcome group
Inflammation markers · Cardiovascular
Source sentences
Summary
rAAV.Tβ4-treated animals displayed lower perivascular leakage and higher blood pressure compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
Summary · context
Fourteen days before LPS injection, the mice were injected with an adeno-associated virus carrying the Tβ4 (rAAV.Tβ4) or LacZ gene (rAAV.LacZ).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2560425402
03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, rAAV.Tβ4 gave higher blood pressure than control.
In plain wordsIn mice with sepsis, a virus that raises Tβ4 gene activity gave higher blood pressure than a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseBlood pressure
Study
mousen: not reported in source
LPS-induced sepsis, rAAV.Tβ4 gene transfer
Comparator
rAAV.LacZ control
Outcome group
Blood pressure · Cardiovascular
Source sentences
Summary
rAAV.Tβ4-treated animals displayed lower perivascular leakage and higher blood pressure compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
Summary · context
Fourteen days before LPS injection, the mice were injected with an adeno-associated virus carrying the Tβ4 (rAAV.Tβ4) or LacZ gene (rAAV.LacZ).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2560425403
04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism
In mice with LPS-induced sepsis, the rAAV.Tβ4 group had a higher pericyte count in heart and peripheral muscle samples than control.
In plain wordsIn mice with sepsis, a virus that raises Tβ4 gene activity gave more pericytes in heart and muscle than a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePericyte count in heart and peripheral muscle
Study
mousen: not reported in source
LPS-induced sepsis, rAAV.Tβ4 gene transfer
Comparator
rAAV.LacZ control
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Of note, the rAAV.Tβ4 group showed a higher pericyte count in heart and peripheral muscle samples.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
Summary · context
Fourteen days before LPS injection, the mice were injected with an adeno-associated virus carrying the Tβ4 (rAAV.Tβ4) or LacZ gene (rAAV.LacZ).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2560425404
05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In mice with LPS-induced sepsis, Tβ4 treatment reduced mortality compared with control.
In plain wordsIn mice with sepsis, a virus that raises Tβ4 gene activity reduced deaths compared with a control.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMortality
Study
mousen: not reported in source
LPS-induced sepsis, rAAV.Tβ4 gene transfer
Comparator
rAAV.LacZ control
Outcome group
Mortality · Whole body
Source sentences
Summary
Finally, Tβ4-treatment reduced mortality compared to control.
2 context sentences(design, population, supporting numbers)
Summary · context
Here, we analyzed whether treatment with Tβ4 is able to reduce the pericytes loss in lipopolysaccharides (LPS)-induced sepsis and to improve the hemodynamic function and survival in C57BL/6 mice.
Summary · context
Fourteen days before LPS injection, the mice were injected with an adeno-associated virus carrying the Tβ4 (rAAV.Tβ4) or LacZ gene (rAAV.LacZ).
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2560425405

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

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