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Study · Not a test of the peptide alone · 2015

3 results

New labeled derivatives of the neuroprotective peptide colivelin: synthesis, characterization, and first in vitro and in vivo applications.

Kostomoiri M, Zikos C, Benaki D, Triantis C, Sagnou M, Paravatou-Petsotas M, Papadaki A, Boleti H, Papadopoulos M, Pirmettis I, Pelecanou M, Livaniou E

Archives of biochemistry and biophysics6 Jan 2015Cited by 3 (Europe PMC)

PMID25575783 (opens in a new tab)DOI10.1016/j.abb.2014.12.027 (opens in a new tab)PepBankPUB-25575783
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Pharmacokinetics

    In healthy Swiss Albino mice, 0.58% of the administered radioactivity from a (99m)Tc-labeled colivelin derivative was in the brain 2 min after injection.

    In plain wordsIn mice, 0.58% of a radiolabeled colivelin derivative reached the brain 2 minutes after injection.

    Peptide
    Humanin
    Outcome
    Not applicableBrain uptake of (99m)Tc-labeled colivelin derivative
    Study

    mousen: not reported in source

    healthy Swiss Albino mice
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Brain radioactivity
    0.58 % of administered radioactivity
    mouse brain, 2 min after injection

    Source sentences

    Summary
    finally, the (99m)Tc-radiolabeled derivative of CL was used in in vivo biodistribution studies in healthy Swiss Albino mice, where 0.58% of the radioactivity administered was measured in the mouse brain 2min after injection.
    1 context sentence
    Summary · context
    Within this framework, three CL derivatives bearing suitable tags, i.e., the fluorescent moiety FITC, the streptavidin-counterpart biotinyl-group, and the (99m)Tc-radiometal chelating unit dimethylGly-Ser-Cys, were developed and subsequently applied in biological evaluation experiments.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Activity measurement

    In confocal microscopy, a FITC-labeled colivelin derivative showed specific binding at the periphery of F11 cells.

    In plain wordsIn cells, a fluorescent colivelin derivative bound to the edge of F11 cells.

    Peptide
    Humanin
    Outcome
    Not applicableBinding of FITC-labeled colivelin derivative to F11 cells
    Study

    n: not reported in source

    F11 cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    the FITC-labeled derivative of CL was used in confocal microscopy, where specific binding at the periphery of F11 cells was observed
    1 context sentence
    Summary · context
    Within this framework, three CL derivatives bearing suitable tags, i.e., the fluorescent moiety FITC, the streptavidin-counterpart biotinyl-group, and the (99m)Tc-radiometal chelating unit dimethylGly-Ser-Cys, were developed and subsequently applied in biological evaluation experiments.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cell-free)Activity measurement

    In an ELISA-type assay, a biotin-labeled colivelin derivative showed specific, concentration-dependent binding to the β-amyloid peptide.

    In plain wordsIn lab tests, a biotin-labeled colivelin derivative bound to the amyloid beta peptide, and more of it bound at higher concentrations.

    Peptide
    Humanin
    Outcome
    Not applicableBinding of biotin-labeled colivelin derivative to β-amyloid peptide
    Study

    n: not reported in source

    ELISA-type assay
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    the biotin-labeled derivative of CL was used in an in-house developed ELISA-type assay, where specific and concentration-dependent binding with the β-amyloid peptide of AD was shown
    1 context sentence
    Summary · context
    Within this framework, three CL derivatives bearing suitable tags, i.e., the fluorescent moiety FITC, the streptavidin-counterpart biotinyl-group, and the (99m)Tc-radiometal chelating unit dimethylGly-Ser-Cys, were developed and subsequently applied in biological evaluation experiments.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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