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Study · Animal study (in vivo) · mouse · 2015

12 results

Protective effect of carnosine on febrile seizures in immature mice.

Dai YJ, Wu DC, Feng B, Hou WW, Xu CL, Ohtsu H, Chen Z, Hu WW

Neuroscience letters3 Jan 2015Cited by 10 (Europe PMC)

PMID25562630 (opens in a new tab)DOI10.1016/j.neulet.2014.12.061 (opens in a new tab)PepBankPUB-25562630
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immature mice, carnosine injection significantly increased febrile seizure latency in a dose-dependent manner.

    In plain wordsIn immature mice, carnosine injection significantly delayed febrile seizures, with effects that depended on dose.

    Peptide
    L-carnosine
    Outcome
    IncreaseFebrile seizure latency
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Injection of carnosine significantly increased the latency and decreased the duration of FSs in a dose-dependent manner.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In immature mice, carnosine injection significantly decreased febrile seizure duration in a dose-dependent manner.

    In plain wordsIn immature mice, carnosine injection significantly shortened febrile seizures, with effects that depended on dose.

    Peptide
    L-carnosine
    Outcome
    DecreaseFebrile seizure duration
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Injection of carnosine significantly increased the latency and decreased the duration of FSs in a dose-dependent manner.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In immature mice, α-FMH completely abolished the protective effect of carnosine against febrile seizures.

    In plain wordsIn immature mice, α-FMH completely removed carnosine protection against febrile seizures.

    Peptide
    L-carnosine
    Outcome
    No significant changeProtection with histidine decarboxylase inhibition
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective effect of carnosine or histidine was completely abolished by α-fluoromethylhistidine (α-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In HDC-KO mice, the protective effect of administered carnosine against febrile seizures was completely abolished.

    In plain wordsIn HDC-KO mice, administered carnosine lost its protective effect against febrile seizures.

    Peptide
    L-carnosine
    Outcome
    No significant changeProtection in HDC-KO mice
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The protective effect of carnosine or histidine was completely abolished by α-fluoromethylhistidine (α-FMH), a selective and irreversible histidine decarboxylase inhibitor, or in histidine decarboxylase deficient (HDC-KO) mice.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased cortical carnosine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased cortical carnosine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseCortical carnosine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased hippocampal carnosine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased hippocampal carnosine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal carnosine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased cortical histidine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased cortical histidine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseCortical histidine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased hippocampal histidine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased hippocampal histidine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal histidine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased cortical histamine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased cortical histamine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseCortical histamine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration increased hippocampal histamine levels.

    In plain wordsIn mouse pups, peripheral carnosine administration increased hippocampal histamine levels.

    Peptide
    L-carnosine
    Outcome
    IncreaseHippocampal histamine
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration decreased cortical glutamate content.

    In plain wordsIn mouse pups, peripheral carnosine administration decreased cortical glutamate content.

    Peptide
    L-carnosine
    Outcome
    DecreaseCortical glutamate
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mouse pups, peripheral carnosine administration decreased hippocampal glutamate content.

    In plain wordsIn mouse pups, peripheral carnosine administration decreased hippocampal glutamate content.

    Peptide
    L-carnosine
    Outcome
    DecreaseHippocampal glutamate
    Study

    mousen: not reported in source

    Hyperthermia-induced febrile seizures in immature mice
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Peripheral carnosine administration increased the level of carnosine, histidine and histamine in the cortex and hippocampus of mice pups, but decreased glutamate contents in the cortex and hippocampus.
    1 context sentence
    Summary · context
    The aim of this study was to analyze the anticonvulsant effects of carnosine, an endogenous dipeptide composed of alanine and histidine, on hyperthermia induced seizure in immature mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

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