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Study · In vitro (cells) · bovine · 2015

5 results

Effects of kisspeptin-10 on in vitro proliferation and kisspeptin receptor expression in primary epithelial cell cultures isolated from bovine placental cotyledons of fetuses at the first trimester of pregnancy.

Martino NA, Rizzo A, Pizzi F, Dell'Aquila ME, Sciorsci RL

Theriogenology3 Dec 2014Cited by 15 (Europe PMC)

PMID25549944 (opens in a new tab)DOI10.1016/j.theriogenology.2014.11.033 (opens in a new tab)PepBankPUB-25549944
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In one bovine first-trimester placental epithelial cell line (line A), Kp-10 inhibited cell proliferation.

    In plain wordsIn cells from cow placenta (line A), Kp-10 slowed cell growth.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCell proliferation, line A
    Study

    bovinen: not reported in source

    Primary epithelial cell lines from first-trimester placental cotyledons
    Comparator
    Control cells without Kp-10
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    0.01, 0.1, 1 and 10 μMAs given in this study (bovine).

    Source sentences

    Summary
    Inhibitory (line A) or stimulatory (line B) effects of Kp-10 on cell proliferation were found in different cell lines and observed cell responses were found to be related to Kiss-1R mRNA levels.
    1 context sentence
    Summary · context
    After being characterized for epithelial polygonal morphology, the presence of binucleate cells, male gender, and the expression of cytokeratin and zona occludens 2, cell lines were cultured in a low glucose Dulbecco's Modified Eagle's Medium-based expansion medium in the presence of 0.01, 0.1, 1, and 10 μM Kp-10.
  2. 02LabIn vitro (cells)Efficacy outcome

    In a second bovine first-trimester placental epithelial cell line (line B), Kp-10 stimulated cell proliferation.

    In plain wordsIn cells from cow placenta (line B), Kp-10 increased cell growth.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCell proliferation, line B
    Study

    bovinen: not reported in source

    Primary epithelial cell lines from first-trimester placental cotyledons
    Comparator
    Control cells without Kp-10
    Outcome group
    Cell proliferation and differentiation · Reproductive and sexual health
    Studied dose
    0.01, 0.1, 1 and 10 μMAs given in this study (bovine).

    Source sentences

    Summary
    Inhibitory (line A) or stimulatory (line B) effects of Kp-10 on cell proliferation were found in different cell lines and observed cell responses were found to be related to Kiss-1R mRNA levels.
    1 context sentence
    Summary · context
    After being characterized for epithelial polygonal morphology, the presence of binucleate cells, male gender, and the expression of cytokeratin and zona occludens 2, cell lines were cultured in a low glucose Dulbecco's Modified Eagle's Medium-based expansion medium in the presence of 0.01, 0.1, 1, and 10 μM Kp-10.
  3. 03LabIn vitro (cells)Mechanism

    In line A, where Kp-10 inhibited proliferation, Kiss-1R expression did not vary significantly.

    In plain wordsIn cells from cow placenta (line A), Kp-10 did not significantly change levels of its receptor Kiss-1R.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKiss-1R mRNA expression, line A
    Study

    bovinen: not reported in source

    Primary epithelial cell lines from first-trimester placental cotyledons
    Comparator
    Control cells without Kp-10
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.01, 0.1, 1 and 10 μMAs given in this study (bovine).

    Source sentences

    Summary
    Inhibition of cell proliferation matched with not significant variation of Kiss-1R expression, whereas stimulation of cell proliferation was found to be related to Kiss-1R upregulation.
    1 context sentence
    Summary · context
    After being characterized for epithelial polygonal morphology, the presence of binucleate cells, male gender, and the expression of cytokeratin and zona occludens 2, cell lines were cultured in a low glucose Dulbecco's Modified Eagle's Medium-based expansion medium in the presence of 0.01, 0.1, 1, and 10 μM Kp-10.
  4. 04LabIn vitro (cells)Mechanism

    In line B, where Kp-10 stimulated proliferation, Kiss-1R was upregulated.

    In plain wordsIn cells from cow placenta (line B), Kp-10 raised levels of its receptor Kiss-1R.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseKiss-1R mRNA expression, line B
    Study

    bovinen: not reported in source

    Primary epithelial cell lines from first-trimester placental cotyledons
    Comparator
    Control cells without Kp-10
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    0.01, 0.1, 1 and 10 μMAs given in this study (bovine).

    Source sentences

    Summary
    Inhibition of cell proliferation matched with not significant variation of Kiss-1R expression, whereas stimulation of cell proliferation was found to be related to Kiss-1R upregulation.
    1 context sentence
    Summary · context
    After being characterized for epithelial polygonal morphology, the presence of binucleate cells, male gender, and the expression of cytokeratin and zona occludens 2, cell lines were cultured in a low glucose Dulbecco's Modified Eagle's Medium-based expansion medium in the presence of 0.01, 0.1, 1, and 10 μM Kp-10.
  5. 05LabIn vitro (cells)Efficacy outcome

    In both cell lines, Kp-10 had no effect on progesterone secretion at any tested concentration.

    In plain wordsIn cells from cow placenta, Kp-10 did not change progesterone release at any concentration tested.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeProgesterone secretion
    Study

    bovinen: not reported in source

    Primary epithelial cell lines from first-trimester placental cotyledons
    Comparator
    Control cells without Kp-10
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.01, 0.1, 1 and 10 μMAs given in this study (bovine).

    Source sentences

    Summary
    In both cell lines, no effect of Kp-10 on P4 secretion was found at any tested concentration.
    1 context sentence
    Summary · context
    After being characterized for epithelial polygonal morphology, the presence of binucleate cells, male gender, and the expression of cytokeratin and zona occludens 2, cell lines were cultured in a low glucose Dulbecco's Modified Eagle's Medium-based expansion medium in the presence of 0.01, 0.1, 1, and 10 μM Kp-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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