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Study · In vitro (cells) · 2015

2 results

Effect of thymosin beta 4 in the presence of up-regulation of the insulin-like growth factor-1 signaling pathway on high-glucose-exposed vascular endothelial cells.

Kim S, Kwon J

Molecular and cellular endocrinology23 Dec 2014Cited by 5 (Europe PMC)

PMID25540921 (opens in a new tab)DOI10.1016/j.mce.2014.12.008 (opens in a new tab)PepBankPUB-25540921
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In high-glucose-injured HUVECs, Tβ4 did not alter the insulin-signaling pathway.

    In plain wordsIn cells, Tβ4 did not change the insulin-signaling pathway.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeInsulin-signaling pathway under high-glucose blockade
    Study

    humann: not reported in source

    High-glucose-injured HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Tβ4 did not alter the insulin-signaling pathway
    1 context sentence
    Summary · context
    Thus, the aim of this study was to elucidate the role of Tβ4 in diabetes and the possible involvement of insulin-like growth factor-1 (IGF-1), which affects cellular survival, metabolism, and glucose homeostasis in high-glucose (HG)-injured human umbilical vein endothelial cells (HUVECs).
  2. 02LabIn vitro (cells)Mechanism

    In high-glucose-injured HUVECs, Tβ4 induced overexpression of IGF-1 protein.

    In plain wordsIn cells, Tβ4 raised the amount of IGF-1 protein.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIGF-1 protein expression
    Study

    humann: not reported in source

    High-glucose-injured HUVECs
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    induced overexpression of IGF-1 protein
    1 context sentence
    Summary · context
    Thus, the aim of this study was to elucidate the role of Tβ4 in diabetes and the possible involvement of insulin-like growth factor-1 (IGF-1), which affects cellular survival, metabolism, and glucose homeostasis in high-glucose (HG)-injured human umbilical vein endothelial cells (HUVECs).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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