A randomized study comparing the side effects and hormonal status of triptorelin and leuprorelin following conservative laparoscopic surgery for ovarian endometriosis in Chinese women.

Li Z, Zhang HY, Zhu YJ, Hu YJ, Qu PP

European journal of obstetrics, gynecology, and reproductive biology4 Nov 2014Cited by 14 (Europe PMC)

PMID25461372DOI10.1016/j.ejogrb.2014.10.022PepBankPUB-25461372

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

01HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, bone pain after 9 weeks did not differ between triptorelin and leuprorelin.
In plain wordsIn women after endometrioma surgery, bone pain after 9 weeks did not differ between triptorelin and leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeBone pain after 9 weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Musculoskeletal
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
After 9 weeks, bone pain, hot flashes and sweating, and irregular bleeding were the main side effects and showed no difference between the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137201
02HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, hot flashes after 9 weeks did not differ between triptorelin and leuprorelin.
In plain wordsIn women after endometrioma surgery, hot flashes after 9 weeks did not differ between triptorelin and leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeHot flashes after 9 weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Endocrine and hormones
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
After 9 weeks, bone pain, hot flashes and sweating, and irregular bleeding were the main side effects and showed no difference between the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137202
03HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, sweating after 9 weeks did not differ between triptorelin and leuprorelin.
In plain wordsIn women after endometrioma surgery, sweating after 9 weeks did not differ between triptorelin and leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeSweating after 9 weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Endocrine and hormones
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
After 9 weeks, bone pain, hot flashes and sweating, and irregular bleeding were the main side effects and showed no difference between the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137203
04HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, irregular bleeding after 9 weeks did not differ between triptorelin and leuprorelin.
In plain wordsIn women after endometrioma surgery, irregular bleeding after 9 weeks did not differ between triptorelin and leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeIrregular bleeding after 9 weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
After 9 weeks, bone pain, hot flashes and sweating, and irregular bleeding were the main side effects and showed no difference between the groups.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137204
05HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, anxiety rates were significantly higher with triptorelin than leuprorelin.
In plain wordsIn women after endometrioma surgery, anxiety rates were higher with triptorelin than leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAnxiety
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Mental health and mood
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137205
06HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, depression rates were significantly higher with triptorelin than leuprorelin.
In plain wordsIn women after endometrioma surgery, depression rates were higher with triptorelin than leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseDepression
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Mental health and mood
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137206
07HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, vaginal dryness rates were significantly higher with triptorelin than leuprorelin.
In plain wordsIn women after endometrioma surgery, vaginal dryness rates were higher with triptorelin than leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseVaginal dryness
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137207
08HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, headache rates were significantly higher with triptorelin than leuprorelin.
In plain wordsIn women after endometrioma surgery, headache rates were higher with triptorelin than leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseHeadache
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Nervous system and cognition
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137208
09HumanRandomized controlled trialSafety outcome
In women after endometrioma surgery, acne rates were significantly higher with triptorelin than leuprorelin.
In plain wordsIn women after endometrioma surgery, acne rates were higher with triptorelin than leuprorelin.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAcne
Study
n = 280
Comparator
Leuprorelin
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
Anxiety, depression, vaginal dryness, headache, and acne rates were all significantly higher in triptorelin group than in leuprorelin group.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137209
10HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, FSH differed significantly between triptorelin and leuprorelin at 21 days, with direction unstated.
In plain wordsIn women after endometrioma surgery, FSH differed between triptorelin and leuprorelin at 21 days. The direction was not stated.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedFSH at 21 days
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
A significant difference in FSH (p=0.003), LH (p=0.026) and E2 (p=0.002) levels between the groups were observed after 21 days of the GnRHa treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137210
11HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, LH differed significantly between triptorelin and leuprorelin at 21 days, with direction unstated.
In plain wordsIn women after endometrioma surgery, LH differed between triptorelin and leuprorelin at 21 days. The direction was not stated.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedLH at 21 days
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
A significant difference in FSH (p=0.003), LH (p=0.026) and E2 (p=0.002) levels between the groups were observed after 21 days of the GnRHa treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137211
12HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, E2 differed significantly between triptorelin and leuprorelin at 21 days, with direction unstated.
In plain wordsIn women after endometrioma surgery, E2 differed between triptorelin and leuprorelin at 21 days. The direction was not stated.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedE2 at 21 days
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
A significant difference in FSH (p=0.003), LH (p=0.026) and E2 (p=0.002) levels between the groups were observed after 21 days of the GnRHa treatment.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137212
13HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, FSH was lower with triptorelin than leuprorelin after six weeks.
In plain wordsIn women after endometrioma surgery, FSH was lower with triptorelin than leuprorelin after six weeks.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH at six weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
The FSH (p=0.021) and E2 (p=0.033) levels remained higher in the leuprorelin group than the triptorelin group after six weeks of treatment, but the difference of LH(p=0.917) level was no longer discernible.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137213
14HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, E2 was lower with triptorelin than leuprorelin after six weeks.
In plain wordsIn women after endometrioma surgery, E2 was lower with triptorelin than leuprorelin after six weeks.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseE2 at six weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
The FSH (p=0.021) and E2 (p=0.033) levels remained higher in the leuprorelin group than the triptorelin group after six weeks of treatment, but the difference of LH(p=0.917) level was no longer discernible.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137214
15HumanRandomized controlled trialEfficacy outcome
In women after endometrioma surgery, LH did not differ between triptorelin and leuprorelin after six weeks.
In plain wordsIn women after endometrioma surgery, LH did not differ between triptorelin and leuprorelin after six weeks.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLH at six weeks
Study
n = 280
Comparator
Leuprorelin
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intramuscular · three doses at 4-week intervalsAs given in this study (human).
Source sentences
Summary
The FSH (p=0.021) and E2 (p=0.033) levels remained higher in the leuprorelin group than the triptorelin group after six weeks of treatment, but the difference of LH(p=0.917) level was no longer discernible.
1 context sentence(design, population, supporting numbers)
Summary · context
Thus 142 patients had three doses of i.m. leuprorelin (group A) and 138 patients had three doses of i.m. triptorelin(group B) at 4 weeks intervals after surgical treatment.
Report a problemFND-2546137215

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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A randomized study comparing the side effects and hormonal status of triptorelin and leuprorelin following conservative laparoscopic surgery for ovarian endometriosis in Chinese women.

Summary

Results from this study15

Version history

Subjects

Publication types

MeSH terms

Keywords