Kisspeptin regulates tuberoinfundibular dopaminergic neurones and prolactin secretion in an oestradiol-dependent manner in male and female rats.

Ribeiro AB, Leite CM, Kalil B, Franci CR, Anselmo-Franci JA, Szawka RE

Journal of neuroendocrinology1 Feb 2015Cited by 42 (Europe PMC)

PMID25453900DOI10.1111/jne.12242PepBankPUB-25453900

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomised, estradiol-treated female rats, Kp-10 at 0.6 and 3 nmol increased plasma prolactin.
In plain wordsIn female rats without ovaries but given estradiol, kisspeptin‑10 raised blood prolactin.
Peptide
Kisspeptin-10
Outcome
IncreasePlasma prolactin in OVX E2-treated female rats
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.6 and 3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
Kp-10 at the doses of 0.6 and 3 nmol increased plasma PRL and decreased 4-dihydroxyphenylacetic acid (DOPAC) levels in the ME and NIL of ovariectomised (OVX), E2 -treated rats but had no effect in OVX.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390001
02AnimalAnimal study (in vivo)Mechanism
In ovariectomised, estradiol-treated female rats, Kp-10 at 0.6 and 3 nmol decreased DOPAC levels in the median eminence and neurointermediate lobe.
In plain wordsIn female rats without ovaries but given estradiol, kisspeptin‑10 lowered a marker of dopamine nerve activity in two brain areas.
Peptide
Kisspeptin-10
Outcome
DecreaseDOPAC in median eminence and neurointermediate lobe in OVX E2-treated rats
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.6 and 3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
Kp-10 at the doses of 0.6 and 3 nmol increased plasma PRL and decreased 4-dihydroxyphenylacetic acid (DOPAC) levels in the ME and NIL of ovariectomised (OVX), E2 -treated rats but had no effect in OVX.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390002
03AnimalAnimal study (in vivo)Efficacy outcome
In ovariectomised female rats without estradiol, Kp-10 had no effect on prolactin or DOPAC.
In plain wordsIn female rats without ovaries and without estradiol, kisspeptin‑10 had no effect on prolactin or the dopamine marker.
Peptide
Kisspeptin-10
Outcome
No significant changeProlactin and DOPAC in OVX rats without estradiol
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.6 and 3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
Kp-10 at the doses of 0.6 and 3 nmol increased plasma PRL and decreased 4-dihydroxyphenylacetic acid (DOPAC) levels in the ME and NIL of ovariectomised (OVX), E2 -treated rats but had no effect in OVX.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390003
04AnimalAnimal study (in vivo)Efficacy outcome
In gonad-intact male rats, 3 nmol Kp-10 increased prolactin secretion.
In plain wordsIn male rats, kisspeptin‑10 raised prolactin release.
Peptide
Kisspeptin-10
Outcome
IncreaseProlactin secretion in gonad-intact male rats
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
In gonad-intact males, 3 nmol Kp-10 increased PRL secretion and decreased DOPAC levels in the ME but not in the NIL.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390004
05AnimalAnimal study (in vivo)Mechanism
In gonad-intact male rats, 3 nmol Kp-10 decreased DOPAC levels in the median eminence.
In plain wordsIn male rats, kisspeptin‑10 lowered a marker of dopamine nerve activity in the median eminence.
Peptide
Kisspeptin-10
Outcome
DecreaseDOPAC in median eminence in gonad-intact male rats
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
In gonad-intact males, 3 nmol Kp-10 increased PRL secretion and decreased DOPAC levels in the ME but not in the NIL.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390005
06AnimalAnimal study (in vivo)Mechanism
In gonad-intact male rats, 3 nmol Kp-10 did not decrease DOPAC levels in the neurointermediate lobe.
In plain wordsIn male rats, kisspeptin‑10 did not change the dopamine marker in the neurointermediate lobe of the pituitary.
Peptide
Kisspeptin-10
Outcome
No significant changeDOPAC in neurointermediate lobe in gonad-intact male rats
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3 nmol · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
In gonad-intact males, 3 nmol Kp-10 increased PRL secretion and decreased DOPAC levels in the ME but not in the NIL.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390006
07AnimalAnimal study (in vivo)Efficacy outcome
In castrated male rats given testosterone or estradiol, Kp-10 increased prolactin secretion.
In plain wordsIn castrated male rats given testosterone or estradiol, kisspeptin‑10 raised prolactin release.
Peptide
Kisspeptin-10
Outcome
IncreaseProlactin in castrated male rats given testosterone or estradiol
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
Castrated males treated with either testosterone or E2 also displayed increased PRL secretion and reduced ME DOPAC in response to Kp-10
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390007
08AnimalAnimal study (in vivo)Mechanism
In castrated male rats given testosterone or estradiol, Kp-10 reduced DOPAC in the median eminence.
In plain wordsIn castrated male rats given testosterone or estradiol, kisspeptin‑10 lowered a dopamine marker in the median eminence.
Peptide
Kisspeptin-10
Outcome
DecreaseMedian eminence DOPAC in castrated male rats given testosterone or estradiol
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
Castrated males treated with either testosterone or E2 also displayed increased PRL secretion and reduced ME DOPAC in response to Kp-10
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390008
09AnimalAnimal study (in vivo)Efficacy outcome
In castrated male rats given oil or dihydrotestosterone, prolactin and DOPAC did not respond to Kp-10.
In plain wordsIn castrated male rats given oil or dihydrotestosterone, kisspeptin‑10 did not change prolactin or the dopamine marker.
Peptide
Kisspeptin-10
Outcome
No significant changeProlactin and DOPAC in castrated male rats given oil or dihydrotestosterone
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
whereas castrated rats receiving oil or dihydrotestosterone were unresponsive.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390009
10AnimalAnimal study (in vivo)Efficacy outcome
In female and male rats, the LH response to Kp-10 did not depend on estradiol.
In plain wordsIn female and male rats, the luteinising hormone response to kisspeptin‑10 did not depend on estradiol.
Peptide
Kisspeptin-10
Outcome
Not applicableLH response and dependence on estradiol
Study
Ratn: not reported in source
Female and male rats, i.c.v. injection
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intracerebroventricularAs given in this study (Rat).
Source sentences
Summary
By contrast, the LH response to Kp-10 was not E2 -dependent in either females or males.
1 context sentence(design, population, supporting numbers)
Summary · context
Female and male rats were injected with i.c.v. Kp-10 and evaluated for PRL release and the activity of dopamine terminals in the median eminence (ME) and neurointermediate lobe of the pituitary (NIL).
Report a problemFND-2545390010

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

Keywords

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