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Study · Animal study (in vivo) · mouse · 2015

7 results

Kisspeptin-10 inhibits the migration of breast cancer cells by regulating epithelial-mesenchymal transition.

Song GQ, Zhao Y

Oncology reports24 Nov 2014Cited by 17 (Europe PMC)

PMID25420482 (opens in a new tab)DOI10.3892/or.2014.3619 (opens in a new tab)PepBankPUB-25420482
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with established breast cancer xenograft tumors, kisspeptin‑10 suppressed tumor growth.

    In plain wordsIn mice with breast cancer tumors, kisspeptin‑10 slowed tumor growth.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseXenograft tumor growth
    Study

    mousen: not reported in source

    established breast cancer xenograft tumor models
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Correspondingly, KP-10 suppressed tumor growth in established xenograft tumor models and improved the survival rate of tumor-bearing mice.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In tumor-bearing mice, kisspeptin‑10 improved the survival rate.

    In plain wordsIn mice with breast cancer tumors, kisspeptin‑10 improved survival.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSurvival of tumor-bearing mice
    Study

    mousen: not reported in source

    established breast cancer xenograft tumor models
    Outcome group
    Mortality · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Correspondingly, KP-10 suppressed tumor growth in established xenograft tumor models and improved the survival rate of tumor-bearing mice.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with breast cancer xenograft tumors, kisspeptin‑10 treatment inhibited the formation of intratumoral microvessels.

    In plain wordsIn mice with breast cancer tumors, kisspeptin‑10 reduced the growth of small blood vessels inside tumors.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseIntratumoral microvessel formation
    Study

    mousen: not reported in source

    breast cancer xenograft tumor models
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The formation of intratumoral microvessels was inhibited following treatment with KP-10.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human breast cancer cell lines MDA-MB-231 and MDA-MB-157, kisspeptin‑10 induced apoptosis.

    In plain wordsIn human breast cancer cells, kisspeptin‑10 caused more cells to die by apoptosis.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseApoptosis of breast cancer cells
    Study

    humann: not reported in source

    MDA-MB-231 and MDA-MB-157 breast cancer cells
    Outcome group
    Cell viability and death · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 was observed to induce apoptosis and inhibit the mobility of MDA-MB-231 and MDA-MB-157 cells.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  5. 05LabIn vitro (cells)Efficacy outcome

    In human breast cancer cell lines MDA-MB-231 and MDA-MB-157, kisspeptin‑10 inhibited cell mobility.

    In plain wordsIn human breast cancer cells, kisspeptin‑10 reduced the ability of the cells to move.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseBreast cancer cell mobility
    Study

    humann: not reported in source

    MDA-MB-231 and MDA-MB-157 breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    KP-10 was observed to induce apoptosis and inhibit the mobility of MDA-MB-231 and MDA-MB-157 cells.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  6. 06LabIn vitro (cells)Mechanism

    In human breast cancer cells, kisspeptin‑10 inhibited cell mobility via epithelial-mesenchymal transition (EMT).

    In plain wordsIn human breast cancer cells, kisspeptin‑10 reduced cell movement through a change known as EMT.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableCell mobility via epithelial-mesenchymal transition
    Study

    humann: not reported in source

    MDA-MB-231 and MDA-MB-157 breast cancer cells
    Outcome group
    Cancer cell invasion and metastasis · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Finally, we confirmed that KP-10 inhibited cell mobility via epithelial-mesenchymal transition (EMT).
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.
  7. 07LabIn vitro (cells)Efficacy outcome

    Kisspeptin‑10 suppressed the growth of human umbilical vein endothelial cells (HUVEC) in vitro.

    In plain wordsIn lab-grown human vein cells, kisspeptin‑10 slowed cell growth.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHUVEC growth
    Study

    humann: not reported in source

    human umbilical vein endothelial cells (HUVEC)
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Overall, the present study demonstrated that KP-10 suppressed breast cancer and human umbilical vein endothelial cell (HUVEC) growth both in vivo and in vitro.
    1 context sentence
    Summary · context
    In the present study, we demonstrated the antitumor effects of KP-10 on human breast cancer cell lines, MDA-MB-231 and MDA-MB-157, both in vitro and in vivo.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

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