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Study · In vitro (cells) · rat · 2014

6 results

Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.

Chang CH, Tsai WC, Hsu YH, Pang JH

Molecules (Basel, Switzerland)19 Nov 2014Cited by 83 (Europe PMC)

PMID25415472 (opens in a new tab)PMCIDPMC6271067 (opens in a new tab)DOI10.3390/molecules191119066 (opens in a new tab)PepBankPUB-25415472
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Summary

BPC 157, a pentadecapeptide derived from human gastric juice, has been demonstrated to promote the healing of different tissues, including skin, muscle, bone, ligament and tendon in many animal studies. However, the underlying mechanism has not been fully clarified. The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat. From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157. BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively. The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR. Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone. In conclusion, the BPC 157-induced increase of growth hormone receptor in tendon fibroblasts may potentiate the proliferation-promoting effect of growth hormone and contribute to the healing of tendon.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In rat tendon fibroblasts, BPC‑157 up-regulated growth hormone receptor as one of the most abundantly increased genes in cDNA microarray analysis.

    In plain wordsIn cells from rat tendon, BPC‑157 strongly raised activity of the growth hormone receptor gene.

    Peptide
    BPC-157
    Outcome
    IncreaseGrowth hormone receptor gene expression (cDNA microarray)
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    From the result of cDNA microarray analysis, growth hormone receptor was revealed as one of the most abundantly up-regulated genes in tendon fibroblasts by BPC 157.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.
  2. 02LabIn vitro (cells)Mechanism

    In rat tendon fibroblasts, BPC‑157 increased growth hormone receptor mRNA in a dose- and time-dependent way.

    In plain wordsIn cells from rat tendon, BPC‑157 raised growth hormone receptor mRNA more with higher dose and longer time.

    Peptide
    BPC-157
    Outcome
    IncreaseGrowth hormone receptor mRNA expression
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.
  3. 03LabIn vitro (cells)Mechanism

    In rat tendon fibroblasts, BPC‑157 increased growth hormone receptor protein in a dose- and time-dependent way.

    In plain wordsIn cells from rat tendon, BPC‑157 raised growth hormone receptor protein more with higher dose and longer time.

    Peptide
    BPC-157
    Outcome
    IncreaseGrowth hormone receptor protein expression
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 dose- and time-dependently increased the expression of growth hormone receptor in tendon fibroblasts at both the mRNA and protein levels as measured by RT/real-time PCR and Western blot, respectively.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.

Studies that did not test the peptide alone3

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

  1. 04LabNot a test of BPC-157 aloneIn vitro (cells)Activity measurement

    In rat tendon fibroblasts pretreated with BPC‑157, added growth hormone increased cell proliferation by MTT assay in a dose- and time-dependent way; the abstract reports no comparison with cells not treated with BPC‑157.

    In plain wordsIn cells from rat tendon treated with BPC‑157, adding growth hormone raised cell growth. No cells without BPC‑157 were compared.

    Peptide
    BPC-157
    Outcome
    Not applicableCell proliferation (MTT assay) with growth hormone
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  2. 05LabNot a test of BPC-157 aloneIn vitro (cells)Activity measurement

    In rat tendon fibroblasts pretreated with BPC‑157, added growth hormone increased PCNA expression in a dose- and time-dependent way; the abstract reports no comparison with cells not treated with BPC‑157.

    In plain wordsIn BPC‑157-treated rat tendon cells, adding growth hormone raised a growth marker (PCNA). No cells without BPC‑157 were compared.

    Peptide
    BPC-157
    Outcome
    Not applicablePCNA expression with growth hormone
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Tendon and ligament healing · Musculoskeletal

    Source sentences

    Summary
    The addition of growth hormone to BPC 157-treated tendon fibroblasts dose- and time-dependently increased the cell proliferation as determined by MTT assay and PCNA expression by RT/real-time PCR.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

  3. 06LabNot a test of BPC-157 aloneIn vitro (cells)Mechanism

    In rat tendon fibroblasts pretreated with BPC‑157, growth hormone activated Janus kinase 2 over time; the abstract reports no comparison with cells not treated with BPC‑157.

    In plain wordsIn BPC‑157-treated rat tendon cells, growth hormone switched on Janus kinase 2 over time. No cells without BPC‑157 were compared.

    Peptide
    BPC-157
    Outcome
    Not applicableJanus kinase 2 activation
    Study

    ratn: not reported in source

    Tendon fibroblasts isolated from rat Achilles tendon
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    Janus kinase 2, the downstream signal pathway of growth hormone receptor, was activated time-dependently by stimulating the BPC 157-treated tendon fibroblasts with growth hormone.
    1 context sentence
    Summary · context
    The present study aimed to explore the effect of BPC 157 on tendon fibroblasts isolated from Achilles tendon of male Sprague-Dawley rat.

    In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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