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Study · Animal study (in vivo) · rat · 2014

9 results

Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats.

Chai GS, Duan DX, Ma RH, Shen JY, Li HL, Ma ZW, Luo Y, Wang L, Qi XH, Wang Q, Wang JZ, Wei Z, Mousseau DD, Wang L, Liu G

Neuroscience bulletin12 Nov 2014Cited by 48 (Europe PMC)

PMID25391447 (opens in a new tab)PMCIDPMC5562564 (opens in a new tab)DOI10.1007/s12264-014-1479-3 (opens in a new tab)PepBankPUB-25391447
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, treatment with HN increased the number of dendritic branches.

    In plain wordsIn rats, humanin treatment increased the number of branches on brain cell extensions.

    Peptide
    Humanin
    Outcome
    IncreaseNumber of dendritic branches
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ(1-42).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, treatment with HN increased the density of dendritic spines.

    In plain wordsIn rats, humanin treatment increased the density of small contact points on brain cell extensions.

    Peptide
    Humanin
    Outcome
    IncreaseDensity of dendritic spines
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ(1-42).
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, treatment with HN upregulated pre- and post-synaptic protein levels.

    In plain wordsIn rats, humanin treatment raised levels of proteins found at nerve cell connections.

    Peptide
    Humanin
    Outcome
    IncreasePre- and post-synaptic protein levels
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, treatment with HN led to enhanced long-term potentiation.

    In plain wordsIn rats, humanin treatment strengthened a brain signal linked to learning.

    Peptide
    Humanin
    Outcome
    IncreaseLong-term potentiation
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory defici…
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, treatment with HN led to amelioration of the memory deficits induced by Aβ(1-42).

    In plain wordsIn rats, humanin treatment improved the memory problems caused by Aβ(1-42).

    Peptide
    Humanin
    Outcome
    DecreaseAβ(1-42)-induced memory deficits
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the present study, we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory defici…
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, HN attenuated Aβ(1-42)-induced tau hyperphosphorylation.

    In plain wordsIn rats, humanin reduced the tau protein changes caused by Aβ(1-42).

    Peptide
    Humanin
    Outcome
    DecreaseAβ(1-42)-induced tau hyperphosphorylation
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also attenuated Aβ(1-42)-induced tau hyperphosphorylation
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, HN apparently activated PP2A by inhibiting phosphorylation of Tyr307 on its catalytic subunit.

    In plain wordsIn rats, humanin appeared to switch on the PP2A enzyme by blocking a chemical tag on it.

    Peptide
    Humanin
    Outcome
    IncreasePP2A activation via Tyr307 phosphorylation
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also attenuated Aβ(1-42)-induced tau hyperphosphorylation, apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A (PP2A) catalytic subunit and thereby activating PP2A.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats, HN inhibited apoptosis induced by Aβ(1-42).

    In plain wordsIn rats, humanin reduced cell death caused by Aβ(1-42).

    Peptide
    Humanin
    Outcome
    DecreaseAβ(1-42)-induced apoptosis
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also inhibited apoptosis and reduced the oxidative stress induced by Aβ(1-42).
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In rats, HN reduced the oxidative stress induced by Aβ(1-42).

    In plain wordsIn rats, humanin lowered the oxidative stress caused by Aβ(1-42).

    Peptide
    Humanin
    Outcome
    DecreaseAβ(1-42)-induced oxidative stress
    Study

    ratn: not reported in source

    Aβ(1-42)-induced Alzheimer-like model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN also inhibited apoptosis and reduced the oxidative stress induced by Aβ(1-42).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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