Skin-whitening and skin-condition-improving effects of topical oxidized glutathione: a double-blind and placebo-controlled clinical trial in healthy women.

Watanabe F, Hashizume E, Chan GP, Kamimura A

Clinical, cosmetic and investigational dermatology17 Oct 2014Cited by 52 (Europe PMC)

PMID25378941PMCIDPMC4207440DOI10.2147/ccid.s68424PepBankPUB-25378941

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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

01HumanRandomized controlled trialEfficacy outcome
In healthy women, topical GSSG lowered skin melanin index versus placebo from early weeks through study end.
In plain wordsIn healthy women, topical GSSG lowered skin pigment scores compared with placebo.
Peptide
Glutathione
Outcome
DecreaseSkin melanin index
Study
n = 30
Comparator
Placebo lotion
Outcome group
Pigmentation · Skin and wound
Studied dose
2% (weight/weight [w/w]) lotion twice daily · topical · 10 weeksAs given in this study (human).
Measurements
P value
< 0.001
Skin melanin index, GSSG versus placebo at 10 weeks
Source sentences
Summary
The skin melanin index was significantly lower with GSSG treatment than with placebo from the early weeks after the start of the trial through to the end of the study period (at 10 weeks, P<0.001).
3 context sentences(design, population, supporting numbers)
Summary · context
The subjects were 30 healthy adult women aged 30 to 50 years.
Summary · context
The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical trial.
Summary · context
Subjects applied GSSG 2% (weight/weight [w/w]) lotion to one side of the face and a placebo lotion to the other side twice daily for 10 weeks.
Report a problemFND-2537894101
02HumanRandomized controlled trialEfficacy outcome
In healthy women, topical GSSG increased stratum corneum moisture in the latter half of the study versus placebo.
In plain wordsIn healthy women, topical GSSG increased skin moisture compared with placebo.
Peptide
Glutathione
Outcome
IncreaseStratum corneum moisture
Study
n = 30
Comparator
Placebo lotion
Outcome group
Skin and hair · Skin and wound
Studied dose
2% (weight/weight [w/w]) lotion twice daily · topical · 10 weeksAs given in this study (human).
Source sentences
Summary
In addition, in the latter half of the study period GSSG-treated sites had significant increases in moisture content of the stratum corneum, suppression of wrinkle formation, and improvement in skin smoothness.
3 context sentences(design, population, supporting numbers)
Summary · context
The subjects were 30 healthy adult women aged 30 to 50 years.
Summary · context
The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical trial.
Summary · context
Subjects applied GSSG 2% (weight/weight [w/w]) lotion to one side of the face and a placebo lotion to the other side twice daily for 10 weeks.
Report a problemFND-2537894102
03HumanRandomized controlled trialEfficacy outcome
In healthy women, topical GSSG suppressed wrinkle formation in the latter half of the study versus placebo.
In plain wordsIn healthy women, topical GSSG reduced wrinkle formation compared with placebo.
Peptide
Glutathione
Outcome
DecreaseWrinkle formation
Study
n = 30
Comparator
Placebo lotion
Outcome group
Skin and hair · Skin and wound
Studied dose
2% (weight/weight [w/w]) lotion twice daily · topical · 10 weeksAs given in this study (human).
Source sentences
Summary
In addition, in the latter half of the study period GSSG-treated sites had significant increases in moisture content of the stratum corneum, suppression of wrinkle formation, and improvement in skin smoothness.
3 context sentences(design, population, supporting numbers)
Summary · context
The subjects were 30 healthy adult women aged 30 to 50 years.
Summary · context
The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical trial.
Summary · context
Subjects applied GSSG 2% (weight/weight [w/w]) lotion to one side of the face and a placebo lotion to the other side twice daily for 10 weeks.
Report a problemFND-2537894103
04HumanRandomized controlled trialEfficacy outcome
In healthy women, topical GSSG improved skin smoothness in the latter half of the study versus placebo.
In plain wordsIn healthy women, topical GSSG improved skin smoothness compared with placebo.
Peptide
Glutathione
Outcome
IncreaseSkin smoothness
Study
n = 30
Comparator
Placebo lotion
Outcome group
Skin and hair · Skin and wound
Studied dose
2% (weight/weight [w/w]) lotion twice daily · topical · 10 weeksAs given in this study (human).
Source sentences
Summary
In addition, in the latter half of the study period GSSG-treated sites had significant increases in moisture content of the stratum corneum, suppression of wrinkle formation, and improvement in skin smoothness.
3 context sentences(design, population, supporting numbers)
Summary · context
The subjects were 30 healthy adult women aged 30 to 50 years.
Summary · context
The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical trial.
Summary · context
Subjects applied GSSG 2% (weight/weight [w/w]) lotion to one side of the face and a placebo lotion to the other side twice daily for 10 weeks.
Report a problemFND-2537894104
05HumanRandomized controlled trialSafety outcome
In healthy women, topical GSSG caused no marked adverse effects.
In plain wordsIn healthy women, topical GSSG application produced no marked adverse effects.
Peptide
Glutathione
Outcome
Not applicableMarked adverse effects
Study
n = 30
Outcome group
Adverse events · Skin and wound
Studied dose
2% (weight/weight [w/w]) lotion twice daily · topical · 10 weeksAs given in this study (human).
Source sentences
Summary
There were no marked adverse effects from GSSG application.
3 context sentences(design, population, supporting numbers)
Summary · context
The subjects were 30 healthy adult women aged 30 to 50 years.
Summary · context
The study design was a randomized, double-blind, matched-pair, placebo-controlled clinical trial.
Summary · context
Subjects applied GSSG 2% (weight/weight [w/w]) lotion to one side of the face and a placebo lotion to the other side twice daily for 10 weeks.
Report a problemFND-2537894105

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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Keywords

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