Skip to content

Study · In vitro (cells) · mouse · 2015

3 results

Stimulation of δ subunit-containing GABAA receptor by DS1 increases GnRH receptor expression but reduces GnRH mRNA expression in GnRH-producing GT1-7 cells.

Sukhbaatar U, Mijiddorj T, Oride A, Kanasaki H

Endocrine30 Oct 2014Cited by 4 (Europe PMC)

PMID25355308 (opens in a new tab)DOI10.1007/s12020-014-0464-y (opens in a new tab)PepBankPUB-25355308
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In GPR54-overexpressing GT1-7 cells, kisspeptin‑10 stimulated serum-response element (SRE) promoter activity.

    In plain wordsIn mouse nerve-cell lines, kisspeptin‑10 switched on a signaling gene switch called the SRE promoter.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSRE promoter activity with kisspeptin-10 alone
    Study

    mousen: not reported in source

    GPR54-overexpressing GT1-7 mouse hypothalamic GnRH neuronal cells
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In G protein-coupled receptor 54 (GPR54)-overexpressing GT1-7 cells, both DS1 and kisspeptin-10 stimulated SRE promoter activity, and combined treatment with DS1 and kisspeptin further increased SRE promoter activity compared with DS1 or kisspeptin alone.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of DS1, a GABAA α4β3δ receptor agonist, on a strain of mouse hypothalamic immortalized GnRH neuronal cells, the GT1-7 cell line.
  2. 02LabIn vitro (cells)Mechanism

    In GPR54-overexpressing GT1-7 cells, adding kisspeptin‑10 to DS1 further increased SRE promoter activity compared with DS1 alone.

    In plain wordsIn mouse nerve-cell lines, adding kisspeptin‑10 to DS1 raised SRE signaling more than DS1 alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSRE promoter activity, DS1 plus kisspeptin-10 versus DS1 alone
    Study

    mousen: not reported in source

    GPR54-overexpressing GT1-7 mouse hypothalamic GnRH neuronal cells
    Comparator
    DS1 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In G protein-coupled receptor 54 (GPR54)-overexpressing GT1-7 cells, both DS1 and kisspeptin-10 stimulated SRE promoter activity, and combined treatment with DS1 and kisspeptin further increased SRE promoter activity compared with DS1 or kisspeptin alone.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of DS1, a GABAA α4β3δ receptor agonist, on a strain of mouse hypothalamic immortalized GnRH neuronal cells, the GT1-7 cell line.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 03LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In GPR54-overexpressing GT1-7 cells, the combination of DS1 and kisspeptin‑10 increased SRE promoter activity compared with kisspeptin‑10 alone.

    In plain wordsIn mouse nerve-cell lines, DS1 together with kisspeptin‑10 raised SRE signaling more than kisspeptin‑10 alone.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSRE promoter activity, DS1 plus kisspeptin-10 versus kisspeptin-10 alone
    Study

    mousen: not reported in source

    GPR54-overexpressing GT1-7 mouse hypothalamic GnRH neuronal cells
    Comparator
    Kisspeptin-10 alone
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    In G protein-coupled receptor 54 (GPR54)-overexpressing GT1-7 cells, both DS1 and kisspeptin-10 stimulated SRE promoter activity, and combined treatment with DS1 and kisspeptin further increased SRE promoter activity compared with DS1 or kisspeptin alone.
    1 context sentence
    Summary · context
    In the present study, we examined the effect of DS1, a GABAA α4β3δ receptor agonist, on a strain of mouse hypothalamic immortalized GnRH neuronal cells, the GT1-7 cell line.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.