Adeno-associated viral vector 2.9 thymosin ß4 application attenuates rejection after heart transplantation: results of a preclinical study in the pig.

Postrach J, Schmidt M, Thormann M, Thein E, Burdorf L, Reichart B, Sotlar K, Walz C, Faber C, Bauer A, Schmoeckel M, Kupatt C, Hinkel R

Transplantation1 Oct 2014Cited by 13 (Europe PMC)

PMID25321165DOI10.1097/tp.0000000000000327PepBankPUB-25321165

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In pigs with heterotopic heart transplants, AAV2.9-mediated Tß4 ameliorated graft inflammation compared with AAV2.9.LacZ.
In plain wordsIn pigs with transplanted hearts, a virus that raises Tβ4 gene activity reduced inflammation in the graft versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseInflammation in cardiac allograft
Study
pign = 10
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Inflammation markers · Cardiovascular
Source sentences
Summary
In addition, Tß4 ameliorated inflammation, necrosis, vascular reaction (acute rejection) and in parallel improved capillary density.
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116501
02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In pigs with heterotopic heart transplants, AAV2.9-mediated Tß4 ameliorated graft necrosis compared with AAV2.9.LacZ.
In plain wordsIn pigs with transplanted hearts, a virus that raises Tβ4 gene activity reduced tissue death in the graft versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseNecrosis in cardiac allograft
Study
pign = 10
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Immune response · Cardiovascular
Source sentences
Summary
In addition, Tß4 ameliorated inflammation, necrosis, vascular reaction (acute rejection) and in parallel improved capillary density.
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116502
03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In pigs with heterotopic heart transplants, AAV2.9-mediated Tß4 ameliorated the vascular reaction of acute rejection compared with AAV2.9.LacZ.
In plain wordsIn pigs with transplanted hearts, a virus that raises Tβ4 gene activity reduced the blood vessel reaction of acute rejection versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseVascular reaction (acute rejection)
Study
pign = 10
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Immune response · Cardiovascular
Source sentences
Summary
In addition, Tß4 ameliorated inflammation, necrosis, vascular reaction (acute rejection) and in parallel improved capillary density.
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116503
04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In pigs with heterotopic heart transplants, AAV2.9-mediated Tß4 improved capillary density in the graft compared with AAV2.9.LacZ.
In plain wordsIn pigs with transplanted hearts, a virus that raises Tβ4 gene activity improved tiny blood vessel density in the graft versus a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCapillary density
Study
pign = 10
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
In addition, Tß4 ameliorated inflammation, necrosis, vascular reaction (acute rejection) and in parallel improved capillary density.
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116504
05AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In pigs with heterotopic heart transplants, graft survival was 31±4 days with AAV2.9.Tß4 versus 10±3 days with AAV2.9.LacZ.
In plain wordsIn pigs with transplanted hearts, grafts lasted 31 days with a virus that raises Tβ4 gene activity, versus 10 days with a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseGraft survival
Study
pign = 10
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Mortality · Cardiovascular
Measurements
Graft survival
10 days
AAV2.9.LacZ
Graft survival
31 days
AAV2.9.Tß4
Source sentences
Summary
In addition, graft survival was significantly prolonged (10±3 days AAV2.9.LacZ vs. 31±4 days AAV2.9.Tß4).
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116505
06AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
In mini pigs with heart grafts, subendocardial segment shortening was 15.8% with AAV2.9.Tß4 versus 9.1% with AAV2.9.LacZ.
In plain wordsIn mini pigs with heart grafts, inner wall shortening was 15.8% with a virus that raises Tβ4 gene activity, versus 9.1% with a control virus.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseRegional myocardial function (subendocardial segment shortening)
Study
pign: not reported in source
heterotopic abdominal cardiac allograft transplantation in landrace and Munich mini pigs
Comparator
AAV2.9.LacZ
Outcome group
Heart function · Cardiovascular
Measurements
Subendocardial segment shortening
9.1%
AAV2.9.LacZ
Subendocardial segment shortening
15.8%
AAV2.9.Tß4
Source sentences
Summary
In the mini pig model, regional myocardial function of the grafts was improved by Tß4 transduction compared to LacZ (9.1%±0.9% subendocardial segment shortening in AAV2.9.LacZ vs. 15.8%±2.3% in AAV2.9.Tß4).
2 context sentences(design, population, supporting numbers)
Summary · context
Heterotopic, abdominal transplantation of cardiac allografts into landrace or into Munich mini pigs (n=5 per group) was performed.
Summary · context
Vascuar endothelial growth factor and AAV2.9.Tß4 or AAV2.9.LacZ were added to the autologous blood used for perfusing the grafts for a period of 45 min.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-2532116506

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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