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Study · Ex vivo tissue · rat · 2014

5 results

[Influence exogenous nicotinamide adenine dinucleotide (NAD+) on contractile and bioelectric activity of the rat heart].

Pustovit KB, Kuz'min VS, Sukhova GS

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova1 Apr 2014Cited by 2 (Europe PMC)

PMID25272455 (opens in a new tab)PepBankPUB-25272455
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat atrial myocardium, 10 mcM NAD decreased action potential duration from 45 +/- 0.82 to 39 +/- 1.05 ms.

    In plain wordsIn lab tests with rat atrial tissue, 10 mcM NAD shortened action potentials compared with control experiments.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseAction potential duration at 10 mcM
    Study

    ratn = 8

    Isolated rat heart or atrial myocardium
    Comparator
    Control experiments
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10 mcMAs given in this study (rat).

    Measurements

    Control APD
    45 ms
    Control experiments
    APD
    39 ms
    10 mcM NAD

    Source sentences

    Summary
    NAD+ (1-100 mcM) induces decreasing of action potential duration (APD) in rat atrial myocardium (from 45 +/- 0.82 ms in control experiments to 39 +/- 1.05 (n = 8) and 32 +/- 2 (n = 8) during application of 10 and 100 mcM of NAD+, respectively).
  2. 02LabEx vivo tissueActivity measurement

    In rat atrial myocardium, 100 mcM NAD decreased action potential duration from 45 +/- 0.82 to 32 +/- 2 ms.

    In plain wordsIn lab tests with rat atrial tissue, 100 mcM NAD shortened action potentials compared with control experiments.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    DecreaseAction potential duration at 100 mcM
    Study

    ratn = 8

    Isolated rat heart or atrial myocardium
    Comparator
    Control experiments
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 mcMAs given in this study (rat).

    Measurements

    Control APD
    45 ms
    Control experiments
    APD
    32 ms
    100 mcM NAD

    Source sentences

    Summary
    NAD+ (1-100 mcM) induces decreasing of action potential duration (APD) in rat atrial myocardium (from 45 +/- 0.82 ms in control experiments to 39 +/- 1.05 (n = 8) and 32 +/- 2 (n = 8) during application of 10 and 100 mcM of NAD+, respectively).
  3. 03LabEx vivo tissueActivity measurement

    In rat atrial myocardium, NAD washout significantly increased action potential duration from 45 +/- 0.82 to 74 +/- 1.89 ms.

    In plain wordsIn lab tests with rat atrial tissue, action potentials lengthened during NAD washout.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    IncreaseAction potential duration during washout
    Study

    ratn = 8

    Isolated rat heart or atrial myocardium
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 mcMAs given in this study (rat).

    Measurements

    APD during washout
    74 ms
    100 mcM NAD

    Source sentences

    Summary
    Significant APD increase (from 45 +/- 0.82 ms to 74 +/- 1.89 (n = 8) ms) was observed during washing out of NAD+ (100 mcM).
  4. 04LabEx vivo tissueActivity measurement

    In isolated rat hearts, NAD caused short positive inotropy followed by negative inotropy.

    In plain wordsIn lab tests with rat hearts, NAD briefly increased contraction strength, then decreased it.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    MixedContractile activity
    Study

    ratn: not reported in source

    Isolated rat heart or atrial myocardium
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAD+ (mcM) induces multiphase alternation of contractile activity of isolated rat heart: short positive inotropic action is followed by a negative inotropic phase.

Studies that did not test the peptide alone1

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

  1. 05LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneEx vivo tissueMechanism

    In rat heart tissue, theophylline did not suppress the NAD-induced decrease in action potential duration.

    In plain wordsIn lab tests with rat heart tissue, theophylline did not suppress the action potential shortening induced by NAD.

    Peptide
    NAD+ (nicotinamide adenine dinucleotide)
    Outcome
    No significant changeTheophylline sensitivity
    Study

    ratn: not reported in source

    Isolated rat heart or atrial myocardium
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    NAD+ induced APD decrease was not suppressed by P1-antagonist theophylline.

    In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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