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Study · Ex vivo tissue · wistar rat · 2014

2 results

Peptides stimulate expression of signal molecules in neuronal cultures from animals of different age.

Umnov RS, Lin'kova NS, Khavinson VKh

Bulletin of experimental biology and medicine26 Sept 2014

PMID25257443 (opens in a new tab)DOI10.1007/s10517-014-2646-2 (opens in a new tab)PepBankPUB-25257443
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In rat brain cultures, cortexin stimulated neuronal proliferation at a lower effective concentration than peptide T-33.

    In plain wordsIn lab tests, cortexin stimulated rat neuron proliferation at a lower concentration than peptide T-33.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseConcentration for neuronal proliferation
    Study

    Wistar ratn: not reported in source

    Organotypic brain cultures from young and old rats
    Comparator
    Peptide T-33
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The effective concentration of peptide T-33 stimulating proliferative activity of neurons considerably surpassed that of cortexin.
    1 context sentence
    Summary · context
    Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats.
  2. 02LabEx vivo tissueMechanism

    In rat brain cortex cultures, cortexin and peptide T-33 stimulated serotonin, Ki-67 and vimentin expression, with T-33 most effective.

    In plain wordsIn lab tests, cortexin and T-33 increased serotonin, Ki-67 and vimentin expression in rat brain cortex cells, with T-33 most effective.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseSerotonin, Ki-67 and vimentin expression
    Study

    Wistar ratn: not reported in source

    Organotypic brain cultures from young and old rats
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Cortexin and peptide T-33 stimulated the expression of serotonin, Ki-67, and vimentin in cells of the brain cortex; peptide T-33 was most effective in this respect.
    1 context sentence
    Summary · context
    Molecular mechanisms of the neuroprotective effect of peptide T-33 and cortexin were studied on organotypic cultures of the brain from young and old Wistar rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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