Skip to content

Study · Animal study (in vivo) · mouse · 2014

4 results

Thymosin beta 4 improves dermal burn wound healing via downregulation of receptor of advanced glycation end products in db/db mice.

Kim S, Kwon J

Biochimica et biophysica acta16 Sept 2014Cited by 20 (Europe PMC)

PMID25230158 (opens in a new tab)DOI10.1016/j.bbagen.2014.09.013 (opens in a new tab)PepBankPUB-25230158
Publisher pagePubMedAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice with burn wounds, thymosin beta‑4 improved wound closure.

    In plain wordsIn diabetic mice with burn wounds, thymosin beta‑4 improved wound closure.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseWound closure
    Study

    mousen: not reported in source

    db/db mice with deep second-degree burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg · intradermal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    After treatment, Tβ4 improved wound healing markers such as wound closure, granulation, and vascularization.
    2 context sentences
    Summary · context
    We adapted a dermal burn wound in vivo model in which the dorsal skin of db/db mice was exposed for 10s to 100°C heated water to produce a deep second-degree burn 10mm in diameter.
    Summary · context
    Five mg/kg of Tβ4 was then injected intradermally near the burn wound twice a week for 2weeks.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice with burn wounds, thymosin beta‑4 improved granulation.

    In plain wordsIn diabetic mice with burn wounds, thymosin beta‑4 improved granulation tissue formation.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseGranulation
    Study

    mousen: not reported in source

    db/db mice with deep second-degree burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg · intradermal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    After treatment, Tβ4 improved wound healing markers such as wound closure, granulation, and vascularization.
    2 context sentences
    Summary · context
    We adapted a dermal burn wound in vivo model in which the dorsal skin of db/db mice was exposed for 10s to 100°C heated water to produce a deep second-degree burn 10mm in diameter.
    Summary · context
    Five mg/kg of Tβ4 was then injected intradermally near the burn wound twice a week for 2weeks.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In db/db diabetic mice with burn wounds, thymosin beta‑4 improved vascularization of the wound.

    In plain wordsIn diabetic mice with burn wounds, thymosin beta‑4 improved blood vessel formation in the wound.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVascularization
    Study

    mousen: not reported in source

    db/db mice with deep second-degree burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg · intradermal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    After treatment, Tβ4 improved wound healing markers such as wound closure, granulation, and vascularization.
    2 context sentences
    Summary · context
    We adapted a dermal burn wound in vivo model in which the dorsal skin of db/db mice was exposed for 10s to 100°C heated water to produce a deep second-degree burn 10mm in diameter.
    Summary · context
    Five mg/kg of Tβ4 was then injected intradermally near the burn wound twice a week for 2weeks.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In db/db diabetic mice with burn wounds, thymosin beta‑4 reduced levels of the receptor of advanced glycation end products (RAGE) during wound healing.

    In plain wordsIn diabetic mice with burn wounds, thymosin beta‑4 lowered levels of RAGE, a receptor linked to diabetes damage.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseRAGE level during wound healing
    Study

    mousen: not reported in source

    db/db mice with deep second-degree burn wound
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    5 mg/kg · intradermal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Interestingly, Tβ4 reduced levels of receptor of AGE (RAGE) during the wound healing period.
    2 context sentences
    Summary · context
    We adapted a dermal burn wound in vivo model in which the dorsal skin of db/db mice was exposed for 10s to 100°C heated water to produce a deep second-degree burn 10mm in diameter.
    Summary · context
    Five mg/kg of Tβ4 was then injected intradermally near the burn wound twice a week for 2weeks.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.