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Study · Not a test of the peptide alone · 2013

3 results

S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein.

Li X, Zhao W, Yang H, Zhang J, Ma J

Neural regeneration research1 Sept 2013Cited by 15 (Europe PMC)

PMID25206568 (opens in a new tab)PMCIDPMC4145930 (opens in a new tab)DOI10.3969/j.issn.1673-5374.2013.27.009 (opens in a new tab)PepBankPUB-25206568
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 01LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In neurons exposed to fibrillar amyloid-beta 40, S14G-humanin restored the amyloid-induced rise in intracellular calcium.

    In plain wordsIn lab tests on neurons, a humanin derivative reversed the calcium rise that amyloid-beta caused.

    Peptide
    Humanin
    Outcome
    DecreaseIntracellular calcium with amyloid-beta 40
    Study

    n: not reported in source

    Hippocampal neurons, fibrillar amyloid-beta 40 challenge
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In neurons exposed to fibrillar amyloid-beta 40, S14G-humanin restored the amyloid-induced generation of reactive oxygen species.

    In plain wordsIn lab tests on neurons, a humanin derivative reversed the oxidative stress that amyloid-beta caused.

    Peptide
    Humanin
    Outcome
    DecreaseReactive oxygen species with amyloid-beta 40
    Study

    n: not reported in source

    Hippocampal neurons, fibrillar amyloid-beta 40 challenge
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In neurons exposed to fibrillar amyloid-beta 40, S14G-humanin restored the amyloid-induced loss of mitochondrial membrane potential.

    In plain wordsIn lab tests on neurons, a humanin derivative reversed the drop in mitochondrial membrane potential that amyloid-beta caused.

    Peptide
    Humanin
    Outcome
    IncreaseMitochondrial membrane potential with amyloid-beta 40
    Study

    n: not reported in source

    Hippocampal neurons, fibrillar amyloid-beta 40 challenge
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    Data from this study showed that fibrillar amyloid-beta 40 disturbed cellular ho-meostasis through the cell membrane, increasing intracellular calcium, generating reactive oxygen species, and decreasing the mitochondrial membrane potential. S14G-humanin restored these responses.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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