Arg-Phe-amide-related peptides influence gonadotropin-releasing hormone neurons.

Kelestimur H, Kacar E, Uzun A, Ozcan M, Kutlu S

Neural regeneration research1 Jun 2013Cited by 1 (Europe PMC)

PMID25206468PMCIDPMC4145918DOI10.3969/j.issn.1673-5374.2013.18.009PepBankPUB-25206468

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In GT1-7 cells, kisspeptin‑10 at 100 nmol/L significantly increased GnRH levels after 120 minutes of exposure.
In plain wordsIn lab tests on GnRH cells, kisspeptin‑10 raised GnRH release.
Peptide
Kisspeptin-10
Outcome
IncreaseGnRH release at 120 minutes
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
100 nmol/L · 120 minutesAs given in this study.
Source sentences
Summary
Results showed that 100 nmol/L kisspeptin-10 significantly increased gonadotropin-releasing hormone levels (at 120 minutes of exposure)
Report a problemFND-2520646801
02LabIn vitro (cells)Mechanism
In GT1-7 cells, kisspeptin‑10 at 100 nmol/L significantly increased intracellular calcium concentrations.
In plain wordsIn lab tests on GnRH cells, kisspeptin‑10 raised calcium inside the cells.
Peptide
Kisspeptin-10
Outcome
IncreaseIntracellular calcium concentration
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Studied dose
100 nmol/LAs given in this study.
Source sentences
Summary
Results showed that 100 nmol/L kisspeptin-10 significantly increased gonadotropin-releasing hormone levels (at 120 minutes of exposure) and intracellular calcium concentrations.
Report a problemFND-2520646802

Studies that did not test the peptide alone4

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

03LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In GT1-7 cells, co-treatment with 1 µmol/L gonadotropin-inhibitory hormone attenuated kisspeptin-induced GnRH levels.
In plain wordsIn lab tests on GnRH cells, gonadotropin-inhibitory hormone reduced the GnRH release caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
DecreaseKisspeptin-induced GnRH with gonadotropin-inhibitory hormone
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Co-treatment of kisspeptin with 1 μmol/L gonadotropin-inhibitory hormone or 1 μmol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2520646803
04LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In GT1-7 cells, co-treatment with 1 µmol/L Arg-Phe-amide-related peptide-1 attenuated kisspeptin-induced GnRH levels.
In plain wordsIn lab tests on GnRH cells, RFRP-1 reduced the GnRH release caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
DecreaseKisspeptin-induced GnRH with RFRP-1
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Co-treatment of kisspeptin with 1 μmol/L gonadotropin-inhibitory hormone or 1 μmol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2520646804
05LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In GT1-7 cells, gonadotropin-inhibitory hormone did not affect kisspeptin-induced rises in intracellular calcium.
In plain wordsIn lab tests on GnRH cells, gonadotropin-inhibitory hormone did not change the calcium rise caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
No significant changeKisspeptin-induced calcium with gonadotropin-inhibitory hormone
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Co-treatment of kisspeptin with 1 μmol/L gonadotropin-inhibitory hormone or 1 μmol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2520646805
06LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism
In GT1-7 cells, Arg-Phe-amide-related peptide-1 did not affect kisspeptin-induced rises in intracellular calcium.
In plain wordsIn lab tests on GnRH cells, RFRP-1 did not change the calcium rise caused by kisspeptin.
Peptide
Kisspeptin-10
Outcome
No significant changeKisspeptin-induced calcium with RFRP-1
Study
n: not reported in source
GT1-7 GnRH-expressing cell line
Outcome group
Receptor activity and mechanism · Reproductive and sexual health
Source sentences
Summary
Co-treatment of kisspeptin with 1 μmol/L gonadotropin-inhibitory hormone or 1 μmol/L Arg-Phe-amide-related peptide-1 significantly attenuated levels of kisspeptin-induced gonadotropin-releasing hormone but did not affect kisspeptin-induced elevations of intracellular calcium concentration.
In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.
Report a problemFND-2520646806

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

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