Skip to content

Study · Animal study (in vivo) · rat · 2015

15 results

Carnosine attenuates early brain injury through its antioxidative and anti-apoptotic effects in a rat experimental subarachnoid hemorrhage model.

Zhang ZY, Sun BL, Yang MF, Li DW, Fang J, Zhang S

Cellular and molecular neurobiology2 Sept 2014Cited by 46 (Europe PMC)

PMID25179154 (opens in a new tab)PMCIDPMC11486197 (opens in a new tab)DOI10.1007/s10571-014-0106-1 (opens in a new tab)PepBankPUB-25179154
Source linkPubMedAsk about this study
Jump to 15 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, carnosine improved neurobehavioral deficits at 48 h.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine improved neurobehavioral deficits at 48 h.

    Peptide
    L-carnosine
    Outcome
    DecreaseNeurobehavioral deficits
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood-brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, carnosine attenuated brain edema at 48 h.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced brain swelling at 48 h.

    Peptide
    L-carnosine
    Outcome
    DecreaseBrain edema
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood-brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with subarachnoid hemorrhage, carnosine attenuated blood-brain barrier permeability at 48 h.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced blood-brain barrier permeability at 48 h.

    Peptide
    L-carnosine
    Outcome
    DecreaseBlood-brain barrier permeability
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood-brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine decreased reactive oxygen species at 48 h.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine decreased reactive oxygen species at 48 h.

    Peptide
    L-carnosine
    Outcome
    DecreaseReactive oxygen species
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    We found that intraperitoneal administration of carnosine improved neurobehavioral deficits, attenuated brain edema and blood-brain barrier permeability, and decreased reactive oxygen species level at 48 h following SAH in rat models.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine increased tissue CuZn-SOD activity.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine increased tissue CuZn-SOD activity.

    Peptide
    L-carnosine
    Outcome
    IncreaseCuZn-SOD activity
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment increased tissue copper/zinc superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-Px) enzymatic activities
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine increased tissue GSH-Px activity.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine increased tissue GSH-Px activity.

    Peptide
    L-carnosine
    Outcome
    IncreaseGSH-Px activity
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Carnosine treatment increased tissue copper/zinc superoxide dismutase (CuZn-SOD) and glutathione peroxidase (GSH-Px) enzymatic activities
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced elevated LDH activity.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced elevated LDH activity.

    Peptide
    L-carnosine
    Outcome
    DecreaseLDH activity
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced MDA concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced MDA concentration.

    Peptide
    L-carnosine
    Outcome
    DecreaseMDA concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced 3-NT concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced 3-NT concentration.

    Peptide
    L-carnosine
    Outcome
    Decrease3-NT concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced 8-OHDG concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced 8-OHDG concentration.

    Peptide
    L-carnosine
    Outcome
    Decrease8-OHDG concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced IL-1β concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced IL-1β concentration.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-1β concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced IL-6 concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced IL-6 concentration.

    Peptide
    L-carnosine
    Outcome
    DecreaseIL-6 concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine reduced TNF-α concentration.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced TNF-α concentration.

    Peptide
    L-carnosine
    Outcome
    DecreaseTNF-α concentration
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    and reduced post-SAH elevated lactate dehydrogenase (LDH) activity, the concentration of malondialdehyde (MDA), 3-nitrotyrosine (3-NT), 8-hydroxydeoxyguanosine (8-OHDG), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) in rats.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine attenuated microglia activation.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced microglia activation.

    Peptide
    L-carnosine
    Outcome
    DecreaseMicroglia activation
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine treatment attenuated SAH-induced microglia activation and cortical neuron apoptosis.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In rats with subarachnoid hemorrhage, carnosine attenuated cortical neuron apoptosis.

    In plain wordsIn rats with subarachnoid hemorrhage, carnosine reduced cortical nerve cell death.

    Peptide
    L-carnosine
    Outcome
    DecreaseCortical neuron apoptosis
    Study

    ratn: not reported in source

    Subarachnoid hemorrhage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, carnosine treatment attenuated SAH-induced microglia activation and cortical neuron apoptosis.
    1 context sentence
    Summary · context
    The aim of this study was to examine whether carnosine prevents subarachnoid hemorrhage (SAH)-induced early brain injury (EBI) in rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.