Bendavia, a mitochondria-targeting peptide, improves postinfarction cardiac function, prevents adverse left ventricular remodeling, and restores mitochondria-related gene expression in rats.

Dai W, Shi J, Gupta RC, Sabbah HN, Hale SL, Kloner RA

Journal of cardiovascular pharmacology1 Dec 2014Cited by 68 (Europe PMC)

PMID25165999DOI10.1097/fjc.0000000000000155PepBankPUB-25165999

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, Bendavia reduced scar circumference compared with water.
In plain wordsIn rats after a heart attack, Bendavia made the heart scar smaller than water treatment did.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseScar circumference
Study
ratn = 54
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Measurements
Scar circumference
39.7%
Bendavia
Scar circumference
47.4%
Water
Source sentences
Summary
Bendavia significantly reduced scar circumference (39.7% +/- 2.2%) compared with water treatment (47.4% +/- 0.03%, P = 0.024)
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, Bendavia reduced left ventricular volume by 8.9%.
In plain wordsIn rats after a heart attack, Bendavia reduced the volume of the main heart chamber.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseLeft ventricular volume
Study
ratn = 54
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Measurements
LV volume reduction
8.9%
Bendavia
Source sentences
Summary
reduced left ventricular (LV) volume by 8.9% (P = 0.019).
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, Bendavia improved LV fractional shortening compared with water.
In plain wordsIn rats after a heart attack, Bendavia improved how well the main heart chamber shortens when pumping, compared with water.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseLeft ventricular fractional shortening
Study
ratn = 54
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Measurements
LV fractional shortening
28.8%
Bendavia
LV fractional shortening
23.8%
Water
Source sentences
Summary
LV fractional shortening was significantly improved by Bendavia (28.8% +/- 1.7%) compared with water treatment (23.8% +/- 1.8%, P = 0.047).
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, LV ejection fraction was higher with Bendavia than with water.
In plain wordsIn rats after a heart attack, Bendavia gave a higher ejection fraction than water.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseLeft ventricular ejection fraction
Study
ratn = 54
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated
Measurements
LV ejection fraction
55.3%
Bendavia
LV ejection fraction
49.3%
Water
Source sentences
Summary
LV ejection fraction was higher with Bendavia (55.3% +/- 1.4%) than water treatment (49.3% +/- 1.4%, P = 0.005).
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats after myocardial infarction, apoptosis in the border zone was significantly less with Bendavia than with water.
In plain wordsIn rats after a heart attack, Bendavia reduced heart cell death near the damaged area compared with water.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseApoptosis in the MI border zone
Study
ratn = 24
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Cell viability and death · Cardiovascular
Studied dose
Dose not stated
Measurements
Apoptosis
32%
Bendavia
Apoptosis
41%
Water
Source sentences
Summary
Apoptosis, within the MI border zone, was significantly less in the Bendavia group (32% +/- 3%, n = 12) compared with the water group (41% +/- 2%, n = 12; P = 0.029).
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599905
06AnimalAnimal study (in vivo)Mechanism
In rats after myocardial infarction, Bendavia reversed the reduced mitochondrial function-related gene expression in the MI border.
In plain wordsIn rats after a heart attack, Bendavia restored the activity of mitochondrial genes that was reduced with water.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial function-related gene expression in MI border
Study
ratn: not reported in source
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bendavia reversed mitochondrial function-related gene expression in the MI border, which was largely reduced in water-treated rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599906
07AnimalAnimal study (in vivo)Mechanism
In rats after myocardial infarction, Bendavia improved complex-I activity in the peri-infarcted region.
In plain wordsIn rats after a heart attack, Bendavia improved the activity of a mitochondrial energy enzyme, complex I, near the damaged area.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseComplex-I activity in peri-infarcted region
Study
ratn: not reported in source
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bendavia improved complex-I and -IV activity, and reduced production of reactive oxygen species and cytosolic cytochrome c level in the peri-infarcted region.
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599907
08AnimalAnimal study (in vivo)Mechanism
In rats after myocardial infarction, Bendavia improved complex-IV activity in the peri-infarcted region.
In plain wordsIn rats after a heart attack, Bendavia improved the activity of a mitochondrial energy enzyme, complex IV, near the damaged area.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseComplex-IV activity in peri-infarcted region
Study
ratn: not reported in source
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Mitochondrial function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bendavia improved complex-I and -IV activity, and reduced production of reactive oxygen species and cytosolic cytochrome c level in the peri-infarcted region.
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599908
09AnimalAnimal study (in vivo)Mechanism
In rats after myocardial infarction, Bendavia reduced production of reactive oxygen species in the peri-infarcted region.
In plain wordsIn rats after a heart attack, Bendavia reduced reactive oxygen production near the damaged area.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseReactive oxygen species production in peri-infarcted region
Study
ratn: not reported in source
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bendavia improved complex-I and -IV activity, and reduced production of reactive oxygen species and cytosolic cytochrome c level in the peri-infarcted region.
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599909
10AnimalAnimal study (in vivo)Mechanism
In rats after myocardial infarction, Bendavia reduced the cytosolic cytochrome c level in the peri-infarcted region.
In plain wordsIn rats after a heart attack, Bendavia lowered a cell-death marker, cytochrome c, near the damaged area.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseCytosolic cytochrome c level in peri-infarcted region
Study
ratn: not reported in source
Myocardial infarction by coronary artery ligation
Comparator
Water
Outcome group
Cell viability and death · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Bendavia improved complex-I and -IV activity, and reduced production of reactive oxygen species and cytosolic cytochrome c level in the peri-infarcted region.
1 context sentence(design, population, supporting numbers)
Summary · context
Two hours after coronary artery ligation, rats were randomized to receive chronic Bendavia treatment (n = 28) or water (n = 26).
Report a problemFND-2516599910

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

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