Protective effects of humanin on okadaic Acid-induced neurotoxicities in cultured cortical neurons.

Zhao J, Wang D, Li L, Zhao W, Zhang C

Neurochemical research21 Aug 2014Cited by 14 (Europe PMC)

PMID25142935DOI10.1007/s11064-014-1410-3PepBankPUB-25142935

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In cultured cortical neurons, HN pretreatment produced significant protection against okadaic acid-induced neural insults.
In plain wordsIn brain cells in a dish, humanin pretreatment protected against damage caused by okadaic acid.
Peptide
Humanin
Outcome
DecreaseOkadaic acid-induced neural insults
Study
n: not reported in source
cultured cortical neurons
Comparator
Okadaic acid without HN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of cells with HN produced significant protective effects against OA-induced neural insults, apoptosis, autophagy and tau hyperphosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
We found that administration of OA for 24 h induced neuronal insults, including lactate dehydrogenase released, decreased of cell viability and numbers of living cells, neuronal apoptosis, cells autophagy and tau protein hyperphosphorylation.
Report a problemFND-2514293501
02LabIn vitro (cells)Efficacy outcome
In cultured cortical neurons, HN pretreatment produced significant protection against okadaic acid-induced apoptosis.
In plain wordsIn brain cells in a dish, humanin pretreatment protected against cell death caused by okadaic acid.
Peptide
Humanin
Outcome
DecreaseOkadaic acid-induced apoptosis
Study
n: not reported in source
cultured cortical neurons
Comparator
Okadaic acid without HN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of cells with HN produced significant protective effects against OA-induced neural insults, apoptosis, autophagy and tau hyperphosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
We found that administration of OA for 24 h induced neuronal insults, including lactate dehydrogenase released, decreased of cell viability and numbers of living cells, neuronal apoptosis, cells autophagy and tau protein hyperphosphorylation.
Report a problemFND-2514293502
03LabIn vitro (cells)Efficacy outcome
In cultured cortical neurons, HN pretreatment produced significant protection against okadaic acid-induced autophagy.
In plain wordsIn brain cells in a dish, humanin pretreatment reduced the cell self-digestion process triggered by okadaic acid.
Peptide
Humanin
Outcome
DecreaseOkadaic acid-induced autophagy
Study
n: not reported in source
cultured cortical neurons
Comparator
Okadaic acid without HN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of cells with HN produced significant protective effects against OA-induced neural insults, apoptosis, autophagy and tau hyperphosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
We found that administration of OA for 24 h induced neuronal insults, including lactate dehydrogenase released, decreased of cell viability and numbers of living cells, neuronal apoptosis, cells autophagy and tau protein hyperphosphorylation.
Report a problemFND-2514293503
04LabIn vitro (cells)Efficacy outcome
In cultured cortical neurons, HN pretreatment produced significant protection against okadaic acid-induced tau hyperphosphorylation.
In plain wordsIn brain cells in a dish, humanin pretreatment reduced the tau protein changes triggered by okadaic acid.
Peptide
Humanin
Outcome
DecreaseOkadaic acid-induced tau hyperphosphorylation
Study
n: not reported in source
cultured cortical neurons
Comparator
Okadaic acid without HN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of cells with HN produced significant protective effects against OA-induced neural insults, apoptosis, autophagy and tau hyperphosphorylation.
1 context sentence(design, population, supporting numbers)
Summary · context
We found that administration of OA for 24 h induced neuronal insults, including lactate dehydrogenase released, decreased of cell viability and numbers of living cells, neuronal apoptosis, cells autophagy and tau protein hyperphosphorylation.
Report a problemFND-2514293504
05LabIn vitro (cells)Mechanism
In cultured cortical neurons, okadaic acid inhibited PP2A activity and HN pretreatment significantly attenuated this inhibition.
In plain wordsIn brain cells in a dish, humanin pretreatment reduced the drop in PP2A enzyme activity caused by okadaic acid.
Peptide
Humanin
Outcome
IncreasePP2A activity after okadaic acid
Study
n: not reported in source
cultured cortical neurons
Comparator
Okadaic acid without HN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
We also found that OA treatment inhibited PP2A activity and HN pretreatment significantly attenuated the inhibitory effects of OA.
Report a problemFND-2514293505

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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