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Study · Animal study (in vivo) · 2015

9 results

Increased oligodendrogenesis by humanin promotes axonal remyelination and neurological recovery in hypoxic/ischemic brains.

Chen J, Sun M, Zhang X, Miao Z, Chua BH, Hamdy RC, Zhang QG, Liu CF, Xu X

Hippocampus10 Sept 2014Cited by 12 (Europe PMC)

PMID25139533 (opens in a new tab)DOI10.1002/hipo.22350 (opens in a new tab)PepBankPUB-25139533
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, intraperitoneal HNG pretreatment decreased infarct volume.

    In plain wordsIn newborn animals with brain injury from low oxygen, a humanin derivative given before the injury reduced the damaged brain area.

    Peptide
    Humanin
    Outcome
    DecreaseInfarct volume after H/I, HNG pretreatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study.

    Source sentences

    Summary
    Intraperitoneal HNG pre-treatment decreased infarct volume following H/I injury.
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment 24 h after injury did not reduce infarct volume.

    In plain wordsIn newborn animals with brain injury from low oxygen, a humanin derivative given a day later did not reduce the damaged brain area.

    Peptide
    Humanin
    Outcome
    No significant changeInfarct volume after H/I, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delayed HNG treatment 24 h after H/I injury did not reduce infarct volume but did decrease neurological deficits and brain atrophy.
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment 24 h after injury decreased neurological deficits.

    In plain wordsIn newborn animals with brain injury from low oxygen, a humanin derivative given a day later reduced nerve function problems.

    Peptide
    Humanin
    Outcome
    DecreaseNeurological deficits after H/I, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delayed HNG treatment 24 h after H/I injury did not reduce infarct volume but did decrease neurological deficits and brain atrophy.
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment 24 h after injury decreased brain atrophy.

    In plain wordsIn newborn animals with brain injury from low oxygen, a humanin derivative given a day later reduced brain shrinkage.

    Peptide
    Humanin
    Outcome
    DecreaseBrain atrophy after H/I, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delayed HNG treatment 24 h after H/I injury did not reduce infarct volume but did decrease neurological deficits and brain atrophy.
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment did not attenuate axonal demyelination at 48 h.

    In plain wordsIn newborn animals with brain injury from low oxygen, delayed treatment with a humanin derivative did not reduce loss of nerve insulation at 48 hours.

    Peptide
    Humanin
    Outcome
    No significant changeAxonal demyelination at 48 h, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Delayed HNG treatment did not attenuate axonal demyelination at 48 h after H/I injury.
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment increased axonal remyelination at 14 d.

    In plain wordsIn newborn animals with brain injury from low oxygen, delayed treatment with a humanin derivative increased nerve insulation repair after 14 days.

    Peptide
    Humanin
    Outcome
    IncreaseAxonal remyelination at 14 d, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, at 14 d after H/I injury, delayed HNG treatment increased axonal remyelination, the thickness of corpus callosum at the midline, the number of Olig2(+) /BrdU(+) cells, and levels of brain-derived neurotrophic factor (BDNF).
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment increased the thickness of the corpus callosum at the midline at 14 d.

    In plain wordsIn newborn animals with brain injury from low oxygen, delayed humanin derivative treatment thickened a key brain fiber tract after 14 days.

    Peptide
    Humanin
    Outcome
    IncreaseCorpus callosum thickness at 14 d, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, at 14 d after H/I injury, delayed HNG treatment increased axonal remyelination, the thickness of corpus callosum at the midline, the number of Olig2(+) /BrdU(+) cells, and levels of brain-derived neurotrophic factor (BDNF).
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment increased the number of Olig2(+) /BrdU(+) cells at 14 d.

    In plain wordsIn newborn animals with brain injury from low oxygen, delayed treatment with a humanin derivative increased new myelin-forming cells after 14 days.

    Peptide
    Humanin
    Outcome
    IncreaseOlig2+/BrdU+ cell number at 14 d, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, at 14 d after H/I injury, delayed HNG treatment increased axonal remyelination, the thickness of corpus callosum at the midline, the number of Olig2(+) /BrdU(+) cells, and levels of brain-derived neurotrophic factor (BDNF).
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In a neonatal hypoxic/ischemic brain injury model, delayed HNG treatment increased levels of brain-derived neurotrophic factor (BDNF) at 14 d.

    In plain wordsIn newborn animals with brain injury from low oxygen, delayed treatment with a humanin derivative raised levels of a brain growth factor after 14 days.

    Peptide
    Humanin
    Outcome
    IncreaseBrain-derived neurotrophic factor levels at 14 d, delayed HNG treatment
    Study

    n: not reported in source

    Neonatal hypoxic/ischemic (H/I) brain injury model
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, at 14 d after H/I injury, delayed HNG treatment increased axonal remyelination, the thickness of corpus callosum at the midline, the number of Olig2(+) /BrdU(+) cells, and levels of brain-derived neurotrophic factor (BDNF).
    1 context sentence
    Summary · context
    In this study, we used a 24-amino acid peptide S14G-Humanin (HNG) to examine oligodendrogenesis and neurological functional recovery in a hypoxic/ischemic (H/I) neonatal model.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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