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Study · In vitro (cells) · 2014

3 results

Apollon/Bruce is upregulated by Humanin.

Hashimoto Y, Takeshita Y, Naito M, Uchino H, Matsuoka M

Molecular and cellular biochemistry20 Aug 2014Cited by 4 (Europe PMC)

PMID25138702 (opens in a new tab)DOI10.1007/s11010-014-2182-4 (opens in a new tab)PepBankPUB-25138702
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured cells, the humanin signaling pathway via htHNR/JAKs/STAT3 increased mRNA expression of Apollon/Bruce.

    In plain wordsIn lab cells, humanin signaling raised the amount of messenger RNA for Apollon/Bruce, a cell-death inhibitor.

    Peptide
    Humanin
    Outcome
    IncreaseApollon/Bruce mRNA expression
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that the Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels of mRNA and protein of Apollon/Bruce
  2. 02LabIn vitro (cells)Mechanism

    In cultured cells, the humanin signaling pathway via htHNR/JAKs/STAT3 increased protein expression of Apollon/Bruce.

    In plain wordsIn lab cells, humanin signaling raised the amount of Apollon/Bruce protein, a cell-death inhibitor.

    Peptide
    Humanin
    Outcome
    IncreaseApollon/Bruce protein expression
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here we show that the Humanin signaling pathway via htHNR/JAKs/STAT3 increased the expression levels of mRNA and protein of Apollon/Bruce

Studies that did not test the peptide alone1

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 03LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In cultured neurons, overexpression of Apollon/Bruce inhibited neuronal death caused by the London-type familial AD-linked V642I mutant of amyloid β precursor protein.

    In plain wordsIn lab neurons, making cells produce more Apollon/Bruce reduced cell death caused by an Alzheimer's-linked protein mutant.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal death caused by mutant amyloid β precursor protein
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    overexpression of Apollon/Bruce inhibits neuronal death, caused by a London-type familial AD-linked mutant (V642I) of amyloid β precursor protein.
    1 context sentence
    Summary · context
    A previous study demonstrated that the Humanin-induced activation of the htHNR/JAK2/STAT3 signaling pathway leads to increased expression of SH3 domain-binding protein 5 (SH3BP5), which is an essential effector of Humanin's anti-cell death activity in some cultured neuronal cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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