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Study · Ex vivo tissue · rat · 2014

4 results

Kisspeptin-10 potentiates miniature excitatory postsynaptic currents in the rat supraoptic nucleus.

Yokoyama T, Minami K, Terawaki K, Miyano K, Ogata J, Maruyama T, Takeuchi M, Uezono Y, Ueta Y

Brain research15 Aug 2014Cited by 8 (Europe PMC)

PMID25130664 (opens in a new tab)DOI10.1016/j.brainres.2014.08.020 (opens in a new tab)PepBankPUB-25130664
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In rat supraoptic nucleus slices, kisspeptin‑10 significantly increased the frequency of miniature excitatory postsynaptic currents in a dose-related manner.

    In plain wordsIn rat brain slices, kisspeptin‑10 raised how often small excitatory signals occurred, more at higher doses.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasemEPSC frequency
    Study

    ratn: not reported in source

    rat brain slices, supraoptic nucleus magnocellular neurosecretory cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 nM-1 μMAs given in this study (rat).

    Source sentences

    Summary
    The application of kisspeptin-10 (100 nM-1 μM) significantly increased the frequency of miniature excitatory postsynaptic currents (mEPSCs) in a dose-related manner without affecting the amplitude.
    1 context sentence
    Summary · context
    We examined the effects of kisspeptin-10 on- excitatory synaptic inputs to magnocellular neurosecretory cells (MNCs) including AVP neurons in the supraoptic nucleus (SON) by obtaining in vitro whole-cell patch-clamp recordings from slice preparations of the rat brain.
  2. 02LabEx vivo tissueMechanism

    In rat supraoptic nucleus slices, kisspeptin‑10 did not affect the amplitude of miniature excitatory postsynaptic currents.

    In plain wordsIn rat brain slices, kisspeptin‑10 did not change the size of small excitatory signals.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changemEPSC amplitude
    Study

    ratn: not reported in source

    rat brain slices, supraoptic nucleus magnocellular neurosecretory cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 nM-1 μMAs given in this study (rat).

    Source sentences

    Summary
    The application of kisspeptin-10 (100 nM-1 μM) significantly increased the frequency of miniature excitatory postsynaptic currents (mEPSCs) in a dose-related manner without affecting the amplitude.
    1 context sentence
    Summary · context
    We examined the effects of kisspeptin-10 on- excitatory synaptic inputs to magnocellular neurosecretory cells (MNCs) including AVP neurons in the supraoptic nucleus (SON) by obtaining in vitro whole-cell patch-clamp recordings from slice preparations of the rat brain.
  3. 03LabEx vivo tissueMechanism

    In rat supraoptic nucleus slices, the kisspeptin receptor antagonist kisspeptin-234 significantly attenuated the potentiation of mEPSCs by kisspeptin‑10.

    In plain wordsIn rat brain slices, a kisspeptin receptor blocker weakened the signal boost that kisspeptin‑10 caused.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin-10 potentiation of mEPSCs with kisspeptin-234
    Study

    ratn: not reported in source

    rat brain slices, supraoptic nucleus magnocellular neurosecretory cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 nM-1 μMAs given in this study (rat).

    Source sentences

    Summary
    The kisspeptin-10-induced potentiation of the mEPSCs was significantly attenuated by previous exposure to the kisspeptin receptor antagonist kisspeptin-234 (100 nM) and to the protein kinase C inhibitor bisindolylmaleimide I (20 nM).
    1 context sentence
    Summary · context
    We examined the effects of kisspeptin-10 on- excitatory synaptic inputs to magnocellular neurosecretory cells (MNCs) including AVP neurons in the supraoptic nucleus (SON) by obtaining in vitro whole-cell patch-clamp recordings from slice preparations of the rat brain.
  4. 04LabEx vivo tissueMechanism

    In rat supraoptic nucleus slices, the protein kinase C inhibitor bisindolylmaleimide I significantly attenuated the potentiation of mEPSCs by kisspeptin‑10.

    In plain wordsIn rat brain slices, a protein kinase C blocker weakened the signal boost that kisspeptin‑10 caused.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKisspeptin-10 potentiation of mEPSCs with PKC inhibitor
    Study

    ratn: not reported in source

    rat brain slices, supraoptic nucleus magnocellular neurosecretory cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    100 nM-1 μMAs given in this study (rat).

    Source sentences

    Summary
    The kisspeptin-10-induced potentiation of the mEPSCs was significantly attenuated by previous exposure to the kisspeptin receptor antagonist kisspeptin-234 (100 nM) and to the protein kinase C inhibitor bisindolylmaleimide I (20 nM).
    1 context sentence
    Summary · context
    We examined the effects of kisspeptin-10 on- excitatory synaptic inputs to magnocellular neurosecretory cells (MNCs) including AVP neurons in the supraoptic nucleus (SON) by obtaining in vitro whole-cell patch-clamp recordings from slice preparations of the rat brain.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

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