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Study · Not a test of the peptide alone · 2014

4 results

In vivo growth suppression of CT-26 mouse colorectal cancer cells by adenovirus-expressed small hairpin RNA specifically targeting thymosin beta-4 mRNA.

Chao TC, Chan LC, Ju SY, Tang MC, Liu CY, Chen PM, Tzeng CH, Su Y

Cancer gene therapy15 Aug 2014Cited by 7 (Europe PMC)

PMID25124811 (opens in a new tab)DOI10.1038/cgt.2014.43 (opens in a new tab)PepBankPUB-25124811
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, tumors grown from CT-26 cells with Tβ4 expression already downregulated by virus infection were drastically reduced.

    In plain wordsIn mice, tumors from bowel cancer cells with Tβ4 switched off beforehand were much smaller.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTumor growth from CT-26 cells with Tβ4 already downregulated
    Study

    mousen: not reported in source

    CT-26 cell tumors in nude mice, Tβ4 downregulated by virus infection before growth
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Additionally, tumors grown in nude mice from the CT-26 cells whose Tβ4 expression already been downregulated by virus infection were also drastically reduced.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with tumors from parental CT-26 cells, multiple intratumoral injections of the Tβ4 shRNA viruses caused significant growth arrest.

    In plain wordsIn mice, repeated injections of the Tβ4-silencing virus into bowel cancer tumors stopped tumor growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGrowth of parental CT-26 tumors after intratumoral shRNA virus injection
    Study

    mousen: not reported in source

    tumors from parental CT-26 cells, intratumoral injection
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Most importantly, significant growth arrest of tumors derived from the parental CT-26 cells was observed after multiple intratumoral injections of these viruses.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In CT-26 mouse colorectal cancer cells in culture, adenovirus-expressed shRNA targeting Tβ4 markedly reduced growth.

    In plain wordsIn mouse bowel cancer cells in a dish, switching off Tβ4 with a virus-delivered RNA strongly slowed cell growth.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCT-26 cell growth after Tβ4 shRNA
    Study

    mousen: not reported in source

    CT-26 mouse colorectal cancer cells in culture
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Herein, we demonstrated that infection with recombinant adenovirus expressing an shRNA targeting Tβ4 markedly reduced the growth of and robustly induced apoptosis in CT-26 mouse CRC cells in culture.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In CT-26 mouse colorectal cancer cells in culture, adenovirus-expressed shRNA targeting Tβ4 robustly induced apoptosis.

    In plain wordsIn mouse bowel cancer cells in a dish, switching off Tβ4 with a virus-delivered RNA strongly triggered cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseApoptosis of CT-26 cells after Tβ4 shRNA
    Study

    mousen: not reported in source

    CT-26 mouse colorectal cancer cells in culture
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Herein, we demonstrated that infection with recombinant adenovirus expressing an shRNA targeting Tβ4 markedly reduced the growth of and robustly induced apoptosis in CT-26 mouse CRC cells in culture.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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