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Study · Animal study (in vivo) · mouse · 2014

11 results

Stimulation of glucagon-like peptide-1 receptor through exendin-4 preserves myocardial performance and prevents cardiac remodeling in infarcted myocardium.

DeNicola M, Du J, Wang Z, Yano N, Zhang L, Wang Y, Qin G, Zhuang S, Zhao TC

American journal of physiology. Endocrinology and metabolism12 Aug 2014Cited by 50 (Europe PMC)

PMID25117407 (opens in a new tab)PMCIDPMC4200306 (opens in a new tab)DOI10.1152/ajpendo.00109.2014 (opens in a new tab)PepBankPUB-25117407
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, exendin‑4 improved cardiac function versus infarcted controls.

    In plain wordsIn mice after a heart attack, exendin‑4 improved heart function compared with infarcted controls.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCardiac function
    Study

    mousen: not reported in source

    Myocardial infarction
    Comparator
    Saline-treated myocardial infarction controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with control MI hearts, stimulation of GLP-1R improved cardiac function, which was associated with attenuation of myocardial hypertrophy, the mitigation of interstitial fibrosis, and an increase in survival rate in post-MI hearts.
    2 context sentences
    Summary · context
    3) MI + exendin-4 [infarcted mice that received injections of exendin-4 (0.1 mg/kg ip)].
    Summary · context
    Two weeks later, cardiac function was assessed by echocardiography and an isovolumetrically perfused heart.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, exendin‑4 attenuated myocardial hypertrophy versus infarcted controls.

    In plain wordsIn mice after a heart attack, exendin‑4 reduced heart enlargement compared with infarcted controls.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMyocardial hypertrophy
    Study

    mousen: not reported in source

    Myocardial infarction
    Comparator
    Saline-treated myocardial infarction controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with control MI hearts, stimulation of GLP-1R improved cardiac function, which was associated with attenuation of myocardial hypertrophy, the mitigation of interstitial fibrosis, and an increase in survival rate in post-MI hearts.
    2 context sentences
    Summary · context
    3) MI + exendin-4 [infarcted mice that received injections of exendin-4 (0.1 mg/kg ip)].
    Summary · context
    Two weeks later, cardiac function was assessed by echocardiography and an isovolumetrically perfused heart.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice after myocardial infarction, exendin‑4 mitigated interstitial fibrosis versus infarcted controls.

    In plain wordsIn mice after a heart attack, exendin‑4 reduced heart scarring compared with infarcted controls.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseInterstitial fibrosis
    Study

    mousen: not reported in source

    Myocardial infarction
    Comparator
    Saline-treated myocardial infarction controls
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.1 mg/kg · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with control MI hearts, stimulation of GLP-1R improved cardiac function, which was associated with attenuation of myocardial hypertrophy, the mitigation of interstitial fibrosis, and an increase in survival rate in post-MI hearts.
    2 context sentences
    Summary · context
    3) MI + exendin-4 [infarcted mice that received injections of exendin-4 (0.1 mg/kg ip)].
    Summary · context
    Two weeks later, cardiac function was assessed by echocardiography and an isovolumetrically perfused heart.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In mice after myocardial infarction, exendin‑4 increased survival versus infarcted controls.

    In plain wordsIn mice after a heart attack, exendin‑4 increased survival compared with infarcted controls.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseSurvival rate
    Study

    mousen: not reported in source

    Myocardial infarction
    Comparator
    Saline-treated myocardial infarction controls
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    0.1 mg/kg · intraperitoneal · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Compared with control MI hearts, stimulation of GLP-1R improved cardiac function, which was associated with attenuation of myocardial hypertrophy, the mitigation of interstitial fibrosis, and an increase in survival rate in post-MI hearts.
    2 context sentences
    Summary · context
    3) MI + exendin-4 [infarcted mice that received injections of exendin-4 (0.1 mg/kg ip)].
    Summary · context
    Two weeks later, cardiac function was assessed by echocardiography and an isovolumetrically perfused heart.
  5. 05LabIn vitro (cells)Efficacy outcome

    In peroxide-exposed H9c2 cells, exendin‑4 decreased lactate dehydrogenase leakage.

    In plain wordsIn cells exposed to peroxide, exendin‑4 reduced leakage of a cell injury marker.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseLactate dehydrogenase leakage
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    The exendin-4 treatment decreased lactate dehydrogenase leakage and increased cell survival.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  6. 06LabIn vitro (cells)Efficacy outcome

    In peroxide-exposed H9c2 cells, exendin‑4 increased cell survival.

    In plain wordsIn cells exposed to peroxide, exendin‑4 increased cell survival.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseCell survival
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    The exendin-4 treatment decreased lactate dehydrogenase leakage and increased cell survival.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  7. 07LabIn vitro (cells)Mechanism

    In peroxide-exposed H9c2 cells, exendin‑4 reduced cleaved caspase-3.

    In plain wordsIn cells exposed to peroxide, exendin‑4 reduced cleaved caspase-3.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCleaved caspase-3
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    Notably, this event was also associated with the reduction of cleaved caspase-3 and caspase-9 and attenuation of reactive oxygen species production.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  8. 08LabIn vitro (cells)Mechanism

    In peroxide-exposed H9c2 cells, exendin‑4 reduced cleaved caspase-9.

    In plain wordsIn cells exposed to peroxide, exendin‑4 reduced cleaved caspase-9.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseCleaved caspase-9
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    Notably, this event was also associated with the reduction of cleaved caspase-3 and caspase-9 and attenuation of reactive oxygen species production.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  9. 09LabIn vitro (cells)Mechanism

    In peroxide-exposed H9c2 cells, exendin‑4 attenuated reactive oxygen species production.

    In plain wordsIn cells exposed to peroxide, exendin‑4 reduced reactive oxygen species production.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseReactive oxygen species
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    Notably, this event was also associated with the reduction of cleaved caspase-3 and caspase-9 and attenuation of reactive oxygen species production.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  10. 10LabIn vitro (cells)Mechanism

    In peroxide-exposed H9c2 cells, exendin‑4 improved mitochondrial respiration.

    In plain wordsIn cells exposed to peroxide, exendin‑4 improved mitochondrial respiration.

    Peptide
    Exenatide (exendin-4)
    Outcome
    IncreaseMitochondrial respiration
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    Exendin-4 treatments improved mitochondrial respiration and suppressed the opening of mitochondrial permeability transition pore and protected mitochondria function.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.
  11. 11LabIn vitro (cells)Mechanism

    In peroxide-exposed H9c2 cells, exendin‑4 suppressed mitochondrial permeability transition pore opening.

    In plain wordsIn cells exposed to peroxide, exendin‑4 reduced opening of mitochondrial permeability pores.

    Peptide
    Exenatide (exendin-4)
    Outcome
    DecreaseMitochondrial permeability transition pore opening
    Study

    n: not reported in source

    H9c2 cardiomyoblasts exposed to hydrogen peroxide
    Outcome group
    Mitochondrial function · Cardiovascular
    Studied dose
    100 nmol/lAs given in this study.

    Source sentences

    Summary
    Exendin-4 treatments improved mitochondrial respiration and suppressed the opening of mitochondrial permeability transition pore and protected mitochondria function.
    1 context sentence
    Summary · context
    Furthermore, H9c2 cardiomyoblasts were preconditioned with exendin-4 at a dose of 100 nmol/l and then subjected to hydrogen peroxide exposure at concentrations of 50 and 100 μmol/l.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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