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Study · In vitro (cells) · 2014

6 results

Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens.

Kaiya H, Konno N, Kangawa K, Uchiyama M, Miyazato M

General and comparative endocrinology2 Aug 2014Cited by 8 (Europe PMC)

PMID25093625 (opens in a new tab)DOI10.1016/j.ygcen.2014.07.021 (opens in a new tab)PepBankPUB-25093625
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, GHRP‑6 increased the intracellular Ca2+ concentration.

    In plain wordsIn cells carrying the lungfish GHS-R1a receptor, GHRP‑6 raised calcium levels inside the cells.

    Peptide
    GHRP-6
    Outcome
    IncreaseIntracellular Ca2+ increase
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, the Ca2+ increase induced by GHRP‑6 was twice that induced by ghrelin.

    In plain wordsIn cells carrying the lungfish receptor, GHRP‑6 caused a calcium rise twice as large as ghrelin did.

    Peptide
    GHRP-6
    Outcome
    IncreaseSize of Ca2+ increase compared with ghrelin
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Comparator
    Ghrelin
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The intensity of the Ca(2+) increases induced by GHS-R1a agonists was twice when compared to that induced by ghrelin, although the median effective doses (ED50) were similar, suggesting a long-lasting effect of GHS-R1a agonists with similar affinity.
    1 context sentence
    Summary · context
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.
  3. 03LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, the median effective dose of GHRP‑6 was similar to that of ghrelin.

    In plain wordsIn cells carrying the lungfish receptor, GHRP‑6 and ghrelin had similar median effective doses.

    Peptide
    GHRP-6
    Outcome
    No significant changeED50 compared with ghrelin
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Comparator
    Ghrelin
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The intensity of the Ca(2+) increases induced by GHS-R1a agonists was twice when compared to that induced by ghrelin, although the median effective doses (ED50) were similar, suggesting a long-lasting effect of GHS-R1a agonists with similar affinity.
    1 context sentence
    Summary · context
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.
  4. 04LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, hexarelin increased the intracellular Ca2+ concentration.

    In plain wordsIn cells carrying the lungfish GHS-R1a receptor, hexarelin raised calcium levels inside the cells.

    Peptide
    Hexarelin
    Outcome
    IncreaseIntracellular Ca2+ increase
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.
  5. 05LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, the Ca2+ increase induced by hexarelin was twice that induced by ghrelin.

    In plain wordsIn cells carrying the lungfish receptor, hexarelin caused a calcium rise twice as large as ghrelin did.

    Peptide
    Hexarelin
    Outcome
    IncreaseSize of Ca2+ increase compared with ghrelin
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Comparator
    Ghrelin
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The intensity of the Ca(2+) increases induced by GHS-R1a agonists was twice when compared to that induced by ghrelin, although the median effective doses (ED50) were similar, suggesting a long-lasting effect of GHS-R1a agonists with similar affinity.
    1 context sentence
    Summary · context
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.
  6. 06LabIn vitro (cells)Activity measurement

    In HEK 293 cells expressing lungfish GHS-R1a, the median effective dose of hexarelin was similar to that of ghrelin.

    In plain wordsIn cells carrying the lungfish receptor, hexarelin and ghrelin had similar median effective doses.

    Peptide
    Hexarelin
    Outcome
    No significant changeED50 compared with ghrelin
    Study

    humann: not reported in source

    HEK 293 cells transiently expressing lungfish GHS-R1a
    Comparator
    Ghrelin
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The intensity of the Ca(2+) increases induced by GHS-R1a agonists was twice when compared to that induced by ghrelin, although the median effective doses (ED50) were similar, suggesting a long-lasting effect of GHS-R1a agonists with similar affinity.
    1 context sentence
    Summary · context
    In human embryonic kidney 293 cells transiently expressing lungfish GHS-R1a, rat and bullfrog ghrelin, and two GHS-R1a agonists, GHRP-6 and hexarelin, increased intracellular Ca(2+) concentrations.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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