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Study · Non-randomized trial · 2014

6 results

Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and β-cell function.

Hinshaw L, Schiavon M, Mallad A, Man CD, Basu R, Bharucha AE, Cobelli C, Carter RE, Basu A, Kudva YC

American journal of physiology. Endocrinology and metabolism29 Jul 2014Cited by 31 (Europe PMC)

PMID25074985 (opens in a new tab)PMCIDPMC4166717 (opens in a new tab)DOI10.1152/ajpendo.00199.2014 (opens in a new tab)PepBankPUB-25074985
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In healthy subjects, pramlintide delayed gastric emptying after a mixed meal.

    In plain wordsIn healthy subjects, pramlintide delayed stomach emptying after a mixed meal.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseGastric emptying rate
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    Delayed gastric emptying induced by pramlintide improved total insulin sensitivity and decreased total β-cell responsivity.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.
  2. 02HumanNon-randomized trialEfficacy outcome

    In healthy subjects, pramlintide-induced delayed gastric emptying delayed the peak rate of meal glucose appearance.

    In plain wordsIn healthy subjects, delayed stomach emptying with pramlintide delayed the peak appearance of meal glucose.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseTiming of peak meal glucose appearance
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    With delayed gastric emptying rates, peak rate of meal glucose appearance was delayed, and rate of endogenous glucose production (EGP) was lower.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.
  3. 03HumanNon-randomized trialEfficacy outcome

    In healthy subjects, endogenous glucose production was lower with pramlintide-induced delayed gastric emptying.

    In plain wordsIn healthy subjects, glucose production by the body was lower with delayed stomach emptying from pramlintide.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseEndogenous glucose production rate
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    With delayed gastric emptying rates, peak rate of meal glucose appearance was delayed, and rate of endogenous glucose production (EGP) was lower.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.
  4. 04HumanNon-randomized trialEfficacy outcome

    In healthy subjects, pramlintide-induced delayed gastric emptying improved total insulin sensitivity.

    In plain wordsIn healthy subjects, delayed stomach emptying from pramlintide improved insulin sensitivity.

    Peptide
    Pramlintide (Symlin)
    Outcome
    IncreaseTotal insulin sensitivity
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    Delayed gastric emptying induced by pramlintide improved total insulin sensitivity and decreased total β-cell responsivity.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.
  5. 05HumanNon-randomized trialEfficacy outcome

    In healthy subjects, pramlintide-induced delayed gastric emptying decreased total beta-cell responsivity.

    In plain wordsIn healthy subjects, delayed stomach emptying from pramlintide decreased the response of insulin-producing cells.

    Peptide
    Pramlintide (Symlin)
    Outcome
    DecreaseTotal beta-cell responsivity
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    Delayed gastric emptying induced by pramlintide improved total insulin sensitivity and decreased total β-cell responsivity.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.
  6. 06HumanNon-randomized trialEfficacy outcome

    In healthy subjects, beta-cell function measured by total disposition index did not change with pramlintide-induced delayed gastric emptying.

    In plain wordsIn healthy subjects, beta-cell function did not change with delayed stomach emptying from pramlintide.

    Peptide
    Pramlintide (Symlin)
    Outcome
    No significant changeTotal disposition index
    Study

    n: not reported in source

    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    30 μgAs given in this study (human).

    Source sentences

    Summary
    However, β-cell function as measured by total disposition index did not change.
    2 context sentences
    Summary · context
    To investigate delayed gastric emptying effects on postprandial glucose turnover, insulin sensitivity, and β-cell responsivity and function, as a feasibility study prior to studying patients with type 1 diabetes, we used the triple tracer technique C-peptide and oral minimal model approach in healthy subjects.
    Summary · context
    A single dose of 30 μg of pramlintide administered at the start of a mixed meal was used to delay gastric emptying rates.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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