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Study · Animal study (in vivo) · rat · 2014

4 results

[Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon].

Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, Dem'ianenko SV

Advances in gerontology = Uspekhi gerontologii1 Jan 2014Cited by 3 (Europe PMC)

PMID25051764 (opens in a new tab)PepBankPUB-25051764
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In old rats with hypoxic hypoxia, the study suggested that Pinealon increased neurogenesis.

    In plain wordsIn rats with hypoxic hypoxia, the study suggested that Pinealon increased formation of neurons.

    Peptide
    Pinealon
    Outcome
    IncreaseNeurogenesis
    Study

    ratn: not reported in source

    Old rats with sharp hypoxic hypoxia
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In old rats with hypoxic hypoxia, the study suggested that Pinealon decreased neuroinflammatory reactions to a reference level.

    In plain wordsIn rats with hypoxic hypoxia, the study suggested that Pinealon reduced brain inflammation to a reference level.

    Peptide
    Pinealon
    Outcome
    DecreaseNeuroinflammatory reactions
    Study

    ratn: not reported in source

    Old rats with sharp hypoxic hypoxia
    Comparator
    Reference level
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    it was suggested that in hypoxia of brain conditions Pinealon forwards the increase of the neurogenesis and the decrease neuroinflammatory reactions to a reference level.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In old rats under acute hypoxic hypoxia, Cortexin reduced the propensity for programmed cell death in brain tissue.

    In plain wordsIn rats under acute hypoxic hypoxia, Cortexin reduced the tendency of brain cells to undergo programmed death.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseProgrammed cell death propensity
    Study

    ratn: not reported in source

    Acute hypoxic hypoxia in old rats
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In old rats under acute hypoxic hypoxia, Cortexin maintained high interleukin-6 content.

    In plain wordsIn rats under acute hypoxic hypoxia, Cortexin maintained high interleukin-6 content.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    Not applicableInterleukin-6 content
    Study

    ratn: not reported in source

    Acute hypoxic hypoxia in old rats
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    With the sharp hypoxic hypoxia Cortexin reduces an ability of brain tissue of programmed cells death, but saves the content of interleykin-6 at high level.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

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