Skip to content

Study · In vitro (cells) · chicken · 2012

13 results

Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes.

Wu J, Fu W, Huang Y, Ni Y

Asian-Australasian Journal of Animal Sciences1 Sept 2012Cited by 7 (Europe PMC)

PMID25049685 (opens in a new tab)PMCIDPMC4092939 (opens in a new tab)DOI10.5713/ajas.2012.12189 (opens in a new tab)PepBankPUB-25049685
Read at sourcePubMedAsk about this study
Jump to 13 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Safety outcome

    In cultured chicken hepatocytes, 100 nM Kp-10 did not affect cell viability after 24 h.

    In plain wordsIn chicken liver cells in the lab, 100 nM kisspeptin‑10 did not change cell survival after 24 hours.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeHepatocyte viability at 100 nM
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    The results showed that after 24 h treatment, cells viability was not affected by 100 nM Kp-10, but showed a mild decrease with 1,000 nM Kp-10 compared to the control cells.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  2. 02LabIn vitro (cells)Safety outcome

    In cultured chicken hepatocytes, 1,000 nM Kp-10 caused a mild decrease in cell viability after 24 h versus control.

    In plain wordsIn chicken liver cells in the lab, 1,000 nM kisspeptin‑10 slightly lowered cell survival after 24 hours compared with control cells.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHepatocyte viability at 1,000 nM
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    1,000 nM · 24 hAs given in this study (chicken).

    Source sentences

    Summary
    The results showed that after 24 h treatment, cells viability was not affected by 100 nM Kp-10, but showed a mild decrease with 1,000 nM Kp-10 compared to the control cells.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured chicken hepatocytes, 100 nM Kp-10 raised total cholesterol by 51.23%, which did not reach statistical significance.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 raised total cholesterol, but the rise was not statistically significant.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeTotal cholesterol content
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Measurements

    Total cholesterol increase
    51.23%
    100 nM Kp-10

    Source sentences

    Summary
    Compared with control cells, total cholesterol (Tch) contents in 100 nM treated cells were increased by 51.23%, but did not reach statistical significance
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  4. 04LabIn vitro (cells)Efficacy outcome

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly increased triglyceride levels.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 raised triglyceride levels compared with control cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseTriglyceride content
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    while the level of triglyceride (TG), high density of lipoprotein-cholesterol (HDL-C) and low density of lipoprotein-cholesterol (LDL-C) were significantly increased.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  5. 05LabIn vitro (cells)Efficacy outcome

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly increased HDL-cholesterol levels.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 raised HDL-cholesterol levels compared with control cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseHDL-C content
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    while the level of triglyceride (TG), high density of lipoprotein-cholesterol (HDL-C) and low density of lipoprotein-cholesterol (LDL-C) were significantly increased.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  6. 06LabIn vitro (cells)Efficacy outcome

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly increased LDL-cholesterol levels.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 raised LDL-cholesterol levels compared with control cells.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLDL-C content
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    while the level of triglyceride (TG), high density of lipoprotein-cholesterol (HDL-C) and low density of lipoprotein-cholesterol (LDL-C) were significantly increased.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  7. 07LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, ApoVLDL-II mRNA expression had a tendency to increase with 100 nM Kp-10, without a significant change.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 tended to raise ApoVLDL-II gene activity, but not significantly.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeApoVLDL-II mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    Real-time PCR results showed that ApoVLDL-II mRNA expression had a tendency to increase
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  8. 08LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly down-regulated SREBP-1 mRNA.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 lowered SREBP-1 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSREBP-1 mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-…
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  9. 09LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly down-regulated ACC alpha mRNA.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 lowered ACC alpha gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseACC alpha mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-…
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  10. 10LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly down-regulated CPT1 mRNA.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 lowered CPT1 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCPT1 mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-…
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  11. 11LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly down-regulated HMGCR mRNA.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 lowered HMGCR gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHMGCR mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-…
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  12. 12LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly down-regulated SCD1 mRNA.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 lowered SCD1 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSCD1 mRNA expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    genes including sterol regulatory element-binding protein-1 (SREBP-1), acetyl coenzyme A carboxylase α (ACCα), carnitine palmitoyltransferase 1 (CPT1), 3-hydroxyl-3-methylglutaryl-coenzyme A reductases (HMGCR) and stearyl coenzyme A dehydrogenase-1 (SCD1) mRNA in hepatocytes were significantly down-…
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.
  13. 13LabIn vitro (cells)Mechanism

    In cultured chicken hepatocytes, 100 nM Kp-10 significantly up-regulated SREBP-1 protein expression.

    In plain wordsIn chicken liver cells in the lab, kisspeptin‑10 raised SREBP-1 protein levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSREBP-1 protein expression
    Study

    chickenn: not reported in source

    Primary hepatocytes from chicken embryo livers
    Comparator
    Control cells
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    100 nMAs given in this study (chicken).

    Source sentences

    Summary
    However, contrary to its gene expression, SREBP-1 protein expression was significantly up-regulated by 100 nM Kp-10.
    1 context sentence
    Summary · context
    In order to investigate the direct effect of Kp-10 on lipid metabolism of hepatocytes in birds, cells were separated from embryos livers and cultured in vitro with 0, 100 and 1,000 nM Kp-10, respectively.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.