Effect of Peripheral Administration of Kisspeptin-10 on Dynamic LH Secretion in Prepubertal Ewes.

Wang J, Sun L, Zhang T, Zhou H, Lou Y

Asian-Australasian Journal of Animal Sciences1 Jun 2012Cited by 6 (Europe PMC)

PMID25049626PMCIDPMC4093094DOI10.5713/ajas.2011.11390PepBankPUB-25049626

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, a single intravenous dose of 0.5 mg kisspeptin‑10 significantly increased LH secretion.
In plain wordsIn young ewes, one 0.5 mg dose of kisspeptin‑10 raised LH release compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseLH secretion after single 0.5 mg dose
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Saline (0 mg)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
0.5 mg · intravenous · single administrationAs given in this study (sheep).
Source sentences
Summary
The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection.
Report a problemFND-2504962601
02AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, a single intravenous dose of 1 mg kisspeptin‑10 significantly increased LH secretion.
In plain wordsIn young ewes, one 1 mg dose of kisspeptin‑10 raised LH release compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseLH secretion after single 1 mg dose
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Saline (0 mg)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 mg · intravenous · single administrationAs given in this study (sheep).
Source sentences
Summary
The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection.
Report a problemFND-2504962602
03AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, a single intravenous dose of 2 mg kisspeptin‑10 significantly increased LH secretion.
In plain wordsIn young ewes, one 2 mg dose of kisspeptin‑10 raised LH release compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseLH secretion after single 2 mg dose
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Saline (0 mg)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2 mg · intravenous · single administrationAs given in this study (sheep).
Source sentences
Summary
The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection.
Report a problemFND-2504962603
04AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, the effect of 1 mg kisspeptin‑10 on LH secretion was higher than that of 0.5 mg.
In plain wordsIn young ewes, 1 mg of kisspeptin‑10 raised LH release more than 0.5 mg did.
Peptide
Kisspeptin-10
Outcome
IncreaseLH effect of 1 mg versus 0.5 mg
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Kisspeptin-10 0.5 mg
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 mg · intravenous · single administrationAs given in this study (sheep).
Source sentences
Summary
The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection.
Report a problemFND-2504962604
05AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, the effect of 2 mg kisspeptin‑10 on LH secretion was higher than that of 0.5 mg.
In plain wordsIn young ewes, 2 mg of kisspeptin‑10 raised LH release more than 0.5 mg did.
Peptide
Kisspeptin-10
Outcome
IncreaseLH effect of 2 mg versus 0.5 mg
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Kisspeptin-10 0.5 mg
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
2 mg · intravenous · single administrationAs given in this study (sheep).
Source sentences
Summary
The results showed that single intravenous administration of 0.5, 1 and 2 mg of kisspeptin-10 all could significantly increased LH secretion in prepubertal ewes, and the effect of 1 and 2 mg of kisspeptin-10 on LH secretion was higher than that of 0.5 mg group.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, prepubertal ewes fitted with indwelling jugular catheters were randomly assigned to receive 0, 0.5, 1 or 2 mg of kisspeptin-10 dissolved in saline, and serial blood samples were collected at 15-min intervals for 180 min to analyze the response curves of LH after injection.
Report a problemFND-2504962605
06AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, repeated intravenous kisspeptin‑10 (1 mg, 3 injections at 1 h interval) effectively increased LH secretion versus saline.
In plain wordsIn young ewes, repeated kisspeptin‑10 doses raised LH release compared with saline.
Peptide
Kisspeptin-10
Outcome
IncreaseLH secretion after repeated administration
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Comparator
Saline (0 mg)
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 mg · intravenous · 3 injections at 1 h intervalAs given in this study (sheep).
Source sentences
Summary
The results also showed that repeated intravenous administration of kisspeptin-10 could effectively increase LH secretion
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, prepubertal ewes fitted with indwelling jugular catheters were injected with 0 or 1 mg of kisspeptin-10 dissolved in saline and the injection was repeated 3 times at 1 h interval and serial blood samples were collected at 15-min intervals for 210 min to analyze the response curves o…
Report a problemFND-2504962606
07AnimalAnimal study (in vivo)Efficacy outcome
In prepubertal ewes, repeated administration did not influence the effect of kisspeptin‑10 on LH secretion.
In plain wordsIn young ewes, giving kisspeptin‑10 again did not change how much it raised LH release.
Peptide
Kisspeptin-10
Outcome
No significant changeLH response to repeated versus single administration
Study
sheepn: not reported in source
Prepubertal ewes with indwelling jugular catheters
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 mg · intravenous · 3 injections at 1 h intervalAs given in this study (sheep).
Source sentences
Summary
repeated administration did not influence the effect of kisspeptin-10 on LH secretion in prepubertal ewe.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, prepubertal ewes fitted with indwelling jugular catheters were injected with 0 or 1 mg of kisspeptin-10 dissolved in saline and the injection was repeated 3 times at 1 h interval and serial blood samples were collected at 15-min intervals for 210 min to analyze the response curves o…
Report a problemFND-2504962607

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 09:43 UTC
Study results updated
Version 1
9 Oct 2026, 03:04 UTC
First added · source update from Europe PMC

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