Skip to content

Study · Animal study (in vivo) · mouse · 2014

12 results

Thymosin-β4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction.

Peng H, Xu J, Yang XP, Dai X, Peterson EL, Carretero OA, Rhaleb NE

American journal of physiology. Heart and circulatory physiology11 Jul 2014Cited by 40 (Europe PMC)

PMID25015963 (opens in a new tab)PMCIDPMC4187393 (opens in a new tab)DOI10.1152/ajpheart.00129.2014 (opens in a new tab)PepBankPUB-25015963
Source linkPubMedAsk about this study
Jump to 12 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction, Tβ4 reduced cardiac rupture compared with vehicle.

    In plain wordsIn mice with heart attack, Tβ4 lowered heart rupture compared with vehicle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCardiac rupture
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Cardiovascular events · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    Tβ4 reduced cardiac rupture
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a mouse model of acute myocardial infarction, Tβ4 decreased mortality caused by cardiac rupture.

    In plain wordsIn mice with heart attack, Tβ4 lowered deaths from heart rupture compared with vehicle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMortality from cardiac rupture
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Mortality · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipumpAs given in this study (mouse).

    Source sentences

    Summary
    In a murine model of acute MI, Tβ4 not only decreased mortality rate as a result of cardiac rupture but also significantly improved cardiac function after MI.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 decreased the number of infiltrating inflammatory cells in the heart.

    In plain wordsIn mice with heart attack, Tβ4 reduced the number of immune cells entering the heart tissue.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInfiltrating inflammatory cells
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    a decrease in the numbers of infiltrating inflammatory cells and apoptotic myocytes, a decrease in gelatinolytic activity and ICAM-1 and p53 expression, and an increase in the numbers of CD31-positive cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 decreased the number of apoptotic myocytes.

    In plain wordsIn mice with heart attack, Tβ4 reduced the number of dying heart muscle cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseApoptotic myocytes
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    a decrease in the numbers of infiltrating inflammatory cells and apoptotic myocytes
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 decreased gelatinolytic activity in the heart.

    In plain wordsIn mice with heart attack, Tβ4 reduced the activity of tissue-degrading enzymes in the heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGelatinolytic activity
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    a decrease in gelatinolytic activity and ICAM-1 and p53 expression, and an increase in the numbers of CD31-positive cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 decreased ICAM-1 expression.

    In plain wordsIn mice with heart attack, Tβ4 lowered ICAM-1, an inflammation marker.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseICAM-1 expression
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    a decrease in gelatinolytic activity and ICAM-1 and p53 expression, and an increase in the numbers of CD31-positive cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 decreased p53 expression.

    In plain wordsIn mice with heart attack, Tβ4 lowered p53, a cell-death marker.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Decreasep53 expression
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    a decrease in gelatinolytic activity and ICAM-1 and p53 expression, and an increase in the numbers of CD31-positive cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with myocardial infarction, Tβ4 increased the number of CD31-positive cells.

    In plain wordsIn mice with heart attack, Tβ4 raised the number of cells that line blood vessels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCD31-positive cells
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 7 daysAs given in this study (mouse).

    Source sentences

    Summary
    an increase in the numbers of CD31-positive cells.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction, five-week Tβ4 treatment ameliorated left ventricular dilation.

    In plain wordsIn mice with heart attack, five weeks of Tβ4 reduced enlargement of the main heart chamber.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLeft ventricular dilation
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Five-week treatment with Tβ4 ameliorated left ventricular dilation, improved cardiac function, markedly reduced interstitial collagen fraction, and increased capillary density.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction, five-week Tβ4 treatment improved cardiac function.

    In plain wordsIn mice with heart attack, five weeks of Tβ4 improved heart function compared with vehicle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiac function
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Five-week treatment with Tβ4 ameliorated left ventricular dilation, improved cardiac function, markedly reduced interstitial collagen fraction, and increased capillary density.
    2 context sentences
    Summary · context
    In a murine model of acute MI, Tβ4 not only decreased mortality rate as a result of cardiac rupture but also significantly improved cardiac function after MI.
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction, five-week Tβ4 treatment markedly reduced the interstitial collagen fraction.

    In plain wordsIn mice with heart attack, five weeks of Tβ4 reduced scar-like collagen in heart tissue.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseInterstitial collagen fraction
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Five-week treatment with Tβ4 ameliorated left ventricular dilation, improved cardiac function, markedly reduced interstitial collagen fraction, and increased capillary density.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice with myocardial infarction, five-week Tβ4 treatment increased capillary density.

    In plain wordsIn mice with heart attack, five weeks of Tβ4 raised the density of small blood vessels in the heart.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCapillary density
    Study

    mousen: not reported in source

    myocardial infarction in C57BL/6 mice
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    1.6 mg/kg/day · intraperitoneal via osmotic minipump · 5 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Five-week treatment with Tβ4 ameliorated left ventricular dilation, improved cardiac function, markedly reduced interstitial collagen fraction, and increased capillary density.
    1 context sentence
    Summary · context
    C57BL/6 mice were subjected to MI and treated with either vehicle or Tβ4 (1.6 mg·kg(-1)·day(-1) ip via osmotic minipump) for 7 days or 5 wk.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.