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Study · Animal study (in vivo) · rat · 2014

6 results

Effects of thymosin β4 on wound healing of rat palatal mucosa.

Zhu T, Park HC, Son KM, Kwon JH, Park JC, Yang HC

International journal of molecular medicine2 Jul 2014Cited by 13 (Europe PMC)

PMID24993983 (opens in a new tab)DOI10.3892/ijmm.2014.1832 (opens in a new tab)PepBankPUB-24993983
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with excisional palatal wounds, wound closure was significantly enhanced with Tβ4 treatment.

    In plain wordsIn rats with palate wounds, wounds closed faster with Tβ4 treatment.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreasePalatal wound closure
    Study

    ratn = 6

    excisional palatal wounds, 3 mm in diameter
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the animal model, palatal wound closure was significantly enhanced in rats treated with Tβ4.
    2 context sentences
    Summary · context
    For the in vivo assay, Tβ4 was applied to excisional wounds (3 mm in diameter) that were made in the center of the palate (n=6).
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.
  2. 02LabIn vitro (cells)Efficacy outcome

    In primary cultured rat palatal cells, Tβ4 did not affect cell viability.

    In plain wordsIn cells from rat palate, Tβ4 did not change cell survival.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCell viability
    Study

    ratn: not reported in source

    primary cultured rat palatal (RP) cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1-1,000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 did not affect cell viability and adhesion, but RP cell migration was stimulated by Tβ4 at concentrations of 100 and 1,000 ng/ml.
    1 context sentence
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.
  3. 03LabIn vitro (cells)Efficacy outcome

    In primary cultured rat palatal cells, Tβ4 did not affect cell adhesion.

    In plain wordsIn cells from rat palate, Tβ4 did not change how well cells stuck to the dish.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeCell adhesion
    Study

    ratn: not reported in source

    primary cultured rat palatal (RP) cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1-1,000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 did not affect cell viability and adhesion, but RP cell migration was stimulated by Tβ4 at concentrations of 100 and 1,000 ng/ml.
    1 context sentence
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.
  4. 04LabIn vitro (cells)Efficacy outcome

    In primary cultured rat palatal cells, Tβ4 at 100 and 1,000 ng/ml stimulated cell migration.

    In plain wordsIn cells from rat palate, Tβ4 made the cells move more at the two higher doses.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCell migration
    Study

    ratn: not reported in source

    primary cultured rat palatal (RP) cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    100 and 1,000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 did not affect cell viability and adhesion, but RP cell migration was stimulated by Tβ4 at concentrations of 100 and 1,000 ng/ml.
    1 context sentence
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.
  5. 05LabIn vitro (cells)Mechanism

    In primary cultured rat palatal cells, Tβ4 increased the mRNA and protein expression of MMP2.

    In plain wordsIn cells from rat palate, Tβ4 raised the amount of MMP2, a tissue-remodeling enzyme.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMMP2 mRNA and protein expression
    Study

    ratn: not reported in source

    primary cultured rat palatal (RP) cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1-1,000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 also increased the mRNA and protein expression of MMP2 and VEGF in RP cells.
    1 context sentence
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.
  6. 06LabIn vitro (cells)Mechanism

    In primary cultured rat palatal cells, Tβ4 increased the mRNA and protein expression of VEGF.

    In plain wordsIn cells from rat palate, Tβ4 raised the amount of VEGF, a blood-vessel growth factor.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVEGF mRNA and protein expression
    Study

    ratn: not reported in source

    primary cultured rat palatal (RP) cells
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    1-1,000 ng/mlAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 also increased the mRNA and protein expression of MMP2 and VEGF in RP cells.
    1 context sentence
    Summary · context
    Cell viability, adhesion and migration of primary cultured RP cells were observed in the presence of Tβ4 at various concentrations ranging from 1 to 1,000 ng/ml.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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