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Study · Animal study (in vivo) · mouse · 2014

4 results

Glucagon is essential for adaptive thermogenesis in brown adipose tissue.

Kinoshita K, Ozaki N, Takagi Y, Murata Y, Oshida Y, Hayashi Y

Endocrinology20 Jun 2014Cited by 55 (Europe PMC)

PMID24949663 (opens in a new tab)DOI10.1210/en.2014-1175 (opens in a new tab)PepBankPUB-24949663
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In GCGKO mice, glucagon restored BAT Ucp1 mRNA expression.

    In plain wordsIn mice deficient in proglucagon-derived peptides, glucagon restored expression of a thermogenic gene in brown fat.

    Peptide
    Glucagon
    Outcome
    IncreaseBAT Ucp1 mRNA expression
    Study

    mousen: not reported in source

    GCGKO mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of glucagon restored the expression of Ucp1 mRNA in the BAT as well as the expression of the fibroblast growth factor 21 gene (Fgf21) in the liver.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In GCGKO mice, glucagon restored liver Fgf21 gene expression.

    In plain wordsIn mice deficient in proglucagon-derived peptides, glucagon restored liver Fgf21 gene expression.

    Peptide
    Glucagon
    Outcome
    IncreaseLiver Fgf21 gene expression
    Study

    mousen: not reported in source

    GCGKO mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Administration of glucagon restored the expression of Ucp1 mRNA in the BAT as well as the expression of the fibroblast growth factor 21 gene (Fgf21) in the liver.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In GCGKO mice, glucagon supplementation for 2 weeks resulted in higher plasma Fgf21 levels.

    In plain wordsIn mice deficient in proglucagon-derived peptides, glucagon increased blood Fgf21 levels.

    Peptide
    Glucagon
    Outcome
    IncreasePlasma Fgf21
    Study

    mousen: not reported in source

    GCGKO mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Supplementation with glucagon for 2 weeks resulted in higher plasma Fgf21 levels and improved responses to CL-316,243 in GCGKO mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In GCGKO mice, glucagon supplementation for 2 weeks improved responses to CL-316,243.

    In plain wordsIn mice deficient in proglucagon-derived peptides, glucagon improved responses to a beta-adrenergic agonist.

    Peptide
    Glucagon
    Outcome
    IncreaseResponse to CL-316,243
    Study

    mousen: not reported in source

    GCGKO mice
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated · 2 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Supplementation with glucagon for 2 weeks resulted in higher plasma Fgf21 levels and improved responses to CL-316,243 in GCGKO mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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