Long term exendin-4 treatment reduces food intake and body weight and alters expression of brain homeostatic and reward markers.

Yang Y, Moghadam AA, Cordner ZA, Liang NC, Moran TH

Endocrinology20 Jun 2014Cited by 42 (Europe PMC)

PMID24949661PMCIDPMC4138563DOI10.1210/en.2014-1052PepBankPUB-24949661

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In chow-fed and high-fat-fed rats, exendin‑4 reduced food intake versus vehicle.
In plain wordsIn rats on either diet, exendin‑4 reduced food intake compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseFood intake
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Appetite and food intake · Metabolic and weight
Studied dose
3.2 μg/kg twice daily · intraperitoneal · 9 daysAs given in this study (rat).
Source sentences
Summary
Treatment with EX-4 significantly decreased food intake and BW over the 9-day period in both the standard chow and HF groups.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
Report a problemFND-2494966101
02AnimalAnimal study (in vivo)Efficacy outcome
In chow-fed and high-fat-fed rats, exendin‑4 reduced body weight versus vehicle.
In plain wordsIn rats on either diet, exendin‑4 reduced weight compared with vehicle.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseBody weight
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Body weight · Metabolic and weight
Studied dose
3.2 μg/kg twice daily · intraperitoneal · 9 daysAs given in this study (rat).
Source sentences
Summary
Treatment with EX-4 significantly decreased food intake and BW over the 9-day period in both the standard chow and HF groups.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
Report a problemFND-2494966102
03AnimalAnimal study (in vivo)Mechanism
In rats, exendin‑4 increased ARC POMC expression independently of reduced food intake and body weight.
In plain wordsIn rats, exendin‑4 increased brain POMC expression independently of lower food intake and weight.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseARC POMC expression
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
3.2 μg/kg twice daily · intraperitoneal · 9 daysAs given in this study (rat).
Source sentences
Summary
Treatment with EX-4 increased POMC and decreased NPY expression independent of the reduction of food intake and BW.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
Report a problemFND-2494966103
04AnimalAnimal study (in vivo)Mechanism
In rats, exendin‑4 decreased ARC NPY expression independently of reduced food intake and body weight.
In plain wordsIn rats, exendin‑4 reduced brain NPY expression independently of lower food intake and weight.
Peptide
Exenatide (exendin-4)
Outcome
DecreaseARC NPY expression
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
3.2 μg/kg twice daily · intraperitoneal · 9 daysAs given in this study (rat).
Source sentences
Summary
Treatment with EX-4 increased POMC and decreased NPY expression independent of the reduction of food intake and BW.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
Report a problemFND-2494966104

Studies that did not test the peptide alone2

In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Exenatide (exendin-4).

05AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, both exendin‑4 and pair feeding reversed reduced TH expression, so the result did not isolate a peptide effect.
In plain wordsIn rats, both exendin‑4 and matched food restriction reversed reduced TH expression.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseMesolimbic TH expression
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Mesolimbic TH and D1R gene expression were decreased significantly in chronic HF diet-fed rats, and these changes were reversed in both EX-4 and pair-fed conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2494966105
06AnimalNot a test of Exenatide (exendin-4) aloneAnimal study (in vivo)Mechanism
In high-fat-fed rats, both exendin‑4 and pair feeding reversed reduced D1R expression, so the result did not isolate a peptide effect.
In plain wordsIn rats, both exendin‑4 and matched food restriction reversed reduced D1R expression.
Peptide
Exenatide (exendin-4)
Outcome
IncreaseMesolimbic D1R expression
Study
ratn: not reported in source
Male Sprague Dawley rats on chow or high-fat diet
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Mesolimbic TH and D1R gene expression were decreased significantly in chronic HF diet-fed rats, and these changes were reversed in both EX-4 and pair-fed conditions.
1 context sentence(design, population, supporting numbers)
Summary · context
After 6 weeks of maintenance on a standard chow or a high-fat (HF) diet, male Sprague Dawley rats were treated with EX-4 (3.2 μg/kg, i.p., twice a day) or vehicle for 9 consecutive days.
In this study, Exenatide (exendin-4) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Exenatide (exendin-4).
Report a problemFND-2494966106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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