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Study · Animal study (in vivo) · rat · 2014

8 results

Beneficial effects of thymosin β4 on spinal cord injury in the rat.

Cheng P, Kuang F, Zhang H, Ju G, Wang J

Neuropharmacology14 Jun 2014Cited by 26 (Europe PMC)

PMID24937047 (opens in a new tab)DOI10.1016/j.neuropharm.2014.06.004 (opens in a new tab)PepBankPUB-24937047
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 markedly improved all behavioral assessments of locomotor recovery.

    In plain wordsIn rats with spinal cord injury, Tβ4 improved movement recovery tests compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLocomotor recovery (BBB scale and footprint analysis)
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Locomotor recovery was tested with the Basso-Beattie-Bresnahan scale and a footprint analysis.
    2 context sentences
    Summary · context
    All behavioral assessments were markedly improved with Tβ4 treatment.
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 significantly increased the number of surviving neurons compared with saline at 7 days.

    In plain wordsIn rats with spinal cord injury, Tβ4 treatment left more surviving nerve cells than saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSurviving neurons at 7 days
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Histological examination at 7 days post injury showed that the numbers of surviving neurons and oligodendrocytes were significantly increased in Tβ4-treated animals compared to saline-treated controls.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 significantly increased the number of surviving oligodendrocytes compared with saline at 7 days.

    In plain wordsIn rats with spinal cord injury, Tβ4 treatment left more surviving oligodendrocytes than saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSurviving oligodendrocytes at 7 days
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Histological examination at 7 days post injury showed that the numbers of surviving neurons and oligodendrocytes were significantly increased in Tβ4-treated animals compared to saline-treated controls.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, myelin basic protein levels were 57.8% greater with Tβ4 than with saline.

    In plain wordsIn rats with spinal cord injury, Tβ4 gave higher levels of a myelin marker than saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMyelin basic protein level
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Measurements

    MBP level difference
    57.8%
    Tβ4 vs saline

    Source sentences

    Summary
    Levels of myelin basic protein, a marker of mature oligodendrocytes, in Tβ4-treated rats were 57.8% greater than those in saline-treated controls.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, ED1 expression was reduced by 36.9% with Tβ4 compared with saline.

    In plain wordsIn rats with spinal cord injury, Tβ4 lowered a marker of activated immune cells compared with saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseED1 expression (activated microglia/macrophages)
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Measurements

    ED1 expression reduction
    36.9%
    Tβ4 vs saline

    Source sentences

    Summary
    The expression of ED1, a marker of activated microglia/macrophages, was reduced by 36.9% in the Tβ4-treated group compared to that of the saline-treated group.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 significantly decreased pro-inflammatory cytokine gene expression compared with control.

    In plain wordsIn rats with spinal cord injury, Tβ4 lowered the activity of inflammation genes compared with control.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreasePro-inflammatory cytokine gene expression
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 treatment after SCI was also associated with a significant decrease in pro-inflammatory cytokine gene expression and a significant increase in the mRNA levels of IL-10 compared to the control.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 significantly increased IL-10 mRNA levels compared with control.

    In plain wordsIn rats with spinal cord injury, Tβ4 raised the activity of the IL-10 gene compared with control.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseIL-10 mRNA level
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Inflammation markers · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Tβ4 treatment after SCI was also associated with a significant decrease in pro-inflammatory cytokine gene expression and a significant increase in the mRNA levels of IL-10 compared to the control.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In rats with spinal cord injury, Tβ4 markedly reduced the size of the lesion cavity compared with saline.

    In plain wordsIn rats with spinal cord injury, Tβ4 gave a smaller injury cavity than saline.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLesion cavity size
    Study

    ratn: not reported in source

    spinal cord injury with mild compression
    Comparator
    Saline
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Moreover, the size of lesion cavity delineated by astrocyte scar in the injured spinal cord was markedly reduced in Tβ4-treated animals compared to saline-treated controls.
    1 context sentence
    Summary · context
    Tβ4 or a saline control was administered by intraperitoneal injection 30 min, 3 days, or 5 days after SCI with mild compression in rat.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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