Effects of altering the dose and timing of triptorelin when given as an intravaginal gel for advancing and synchronizing ovulation in weaned sows.

Knox RV, Taibl JN, Breen SM, Swanson ME, Webel SK

Theriogenology2 May 2014Cited by 29 (Europe PMC)

PMID24888686DOI10.1016/j.theriogenology.2014.04.020PepBankPUB-24888686

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study33

28 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In weaned sows, triptorelin gel prolonged estrus compared with placebo.
In plain wordsIn sows, triptorelin gel prolonged estrus compared with placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseEstrus duration, experiment 1
Study
pign = 131
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval and duration of estrus were correlated (P < 0.0001) with estrus duration longer in TG (P < 0.05) compared with Placebo.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868601
02AnimalAnimal study (in vivo)Efficacy outcome
In sows, farrowing rate did not differ between triptorelin gel and placebo groups.
In plain wordsIn sows, farrowing rate did not differ between triptorelin gel and placebo groups.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFarrowing rate, experiment 1
Study
pign = 131
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and total pigs born did not differ (P > 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868605
03AnimalAnimal study (in vivo)Efficacy outcome
In sows, total pigs born did not differ between triptorelin gel and placebo groups.
In plain wordsIn sows, total pigs born did not differ between triptorelin gel and placebo groups.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeTotal pigs born, experiment 1
Study
pign = 131
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and total pigs born did not differ (P > 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868606
04AnimalAnimal study (in vivo)Efficacy outcome
In sows, triptorelin treatment did not affect the wean-to-estrus interval.
In plain wordsIn sows, triptorelin did not change the wean-to-estrus interval compared with untreated controls.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeWean-to-estrus interval, experiment 2
Study
pign = 126
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval was not affected by treatment, but wean-to-ovulation interval was reduced (P < 0.05) by TG-72 and TG-84 compared with TG-96 and Control-96.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868607
05AnimalAnimal study (in vivo)Efficacy outcome
In sows, all triptorelin timing groups had higher ovulation by 48 hours (64%) than Control-96 (34%).
In plain wordsIn sows, all triptorelin timing groups had higher ovulation by 48 hours than Control-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours, experiment 2
Study
pign = 126
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated 40 hours after treatment (P < 0.001) with TG-72 (56.5%) and TG-84 (32.2%) compared with TG-96 and Control-96 (13%) and for all TG treatments 48 hours after treatment (64%) compared with Control-96 (34%, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868616
06AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 48 hours was 81% with triptorelin versus 42% with placebo.
In plain wordsIn sows, ovulation by 48 hours was higher with triptorelin than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours, 200 μg
Study
pign: not reported in source
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after treatment with 200 (81%), 100 (64%), and 25 μg (63%) of TG compared with Placebo (42%).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868602
07AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 48 hours was 64% with triptorelin versus 42% with placebo.
In plain wordsIn sows, ovulation by 48 hours was higher with triptorelin than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours, 100 μg
Study
pign: not reported in source
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
100 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after treatment with 200 (81%), 100 (64%), and 25 μg (63%) of TG compared with Placebo (42%).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868603
08AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 48 hours was 63% with triptorelin versus 42% with placebo.
In plain wordsIn sows, ovulation by 48 hours was higher with triptorelin than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours, 25 μg
Study
pign: not reported in source
weaned sows
Comparator
Placebo
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
25 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after treatment with 200 (81%), 100 (64%), and 25 μg (63%) of TG compared with Placebo (42%).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 1, sows (n = 131) received intravaginal gel containing 0 (Placebo), 25, 100, or 200 μg of TG at 96 hours after weaning and sows were inseminated on each day of standing estrus.
Report a problemFND-2488868604
09AnimalAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 72 hours after weaning shortened the wean-to-ovulation interval versus treatment at 96 hours.
In plain wordsIn sows, triptorelin at 72 hours shortened the wean-to-ovulation interval versus treatment at 96 hours.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseWean-to-ovulation interval, TG-72 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg at 72 versus 96 hours after weaning · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval was not affected by treatment, but wean-to-ovulation interval was reduced (P < 0.05) by TG-72 and TG-84 compared with TG-96 and Control-96.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868608
10AnimalAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 72 hours shortened the wean-to-ovulation interval versus Control-96.
In plain wordsIn sows, triptorelin at 72 hours shortened the wean-to-ovulation interval versus Control-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseWean-to-ovulation interval, TG-72 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval was not affected by treatment, but wean-to-ovulation interval was reduced (P < 0.05) by TG-72 and TG-84 compared with TG-96 and Control-96.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868609
11AnimalAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 84 hours shortened the wean-to-ovulation interval versus treatment at 96 hours.
In plain wordsIn sows, triptorelin at 84 hours shortened the wean-to-ovulation interval versus treatment at 96 hours.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseWean-to-ovulation interval, TG-84 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg at 84 versus 96 hours after weaning · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval was not affected by treatment, but wean-to-ovulation interval was reduced (P < 0.05) by TG-72 and TG-84 compared with TG-96 and Control-96.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868610
12AnimalAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 84 hours shortened the wean-to-ovulation interval versus Control-96.
In plain wordsIn sows, triptorelin at 84 hours shortened the wean-to-ovulation interval versus Control-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseWean-to-ovulation interval, TG-84 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval was not affected by treatment, but wean-to-ovulation interval was reduced (P < 0.05) by TG-72 and TG-84 compared with TG-96 and Control-96.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868611
13AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 40 hours was higher with TG-72 (56.5%) than TG-96.
In plain wordsIn sows, ovulation by 40 hours was higher with TG-72 than TG-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 40 hours, TG-72 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg at 72 versus 96 hours after weaning · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated 40 hours after treatment (P < 0.001) with TG-72 (56.5%) and TG-84 (32.2%) compared with TG-96 and Control-96 (13%) and for all TG treatments 48 hours after treatment (64%) compared with Control-96 (34%, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868612
14AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 40 hours was higher with TG-72 (56.5%) than Control-96 (13%).
In plain wordsIn sows, ovulation by 40 hours was higher with TG-72 than Control-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 40 hours, TG-72 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated 40 hours after treatment (P < 0.001) with TG-72 (56.5%) and TG-84 (32.2%) compared with TG-96 and Control-96 (13%) and for all TG treatments 48 hours after treatment (64%) compared with Control-96 (34%, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868613
15AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 40 hours was higher with TG-84 (32.2%) than TG-96.
In plain wordsIn sows, ovulation by 40 hours was higher with TG-84 than TG-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 40 hours, TG-84 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg at 84 versus 96 hours after weaning · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated 40 hours after treatment (P < 0.001) with TG-72 (56.5%) and TG-84 (32.2%) compared with TG-96 and Control-96 (13%) and for all TG treatments 48 hours after treatment (64%) compared with Control-96 (34%, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868614
16AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 40 hours was higher with TG-84 (32.2%) than Control-96 (13%).
In plain wordsIn sows, ovulation by 40 hours was higher with TG-84 than Control-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 40 hours, TG-84 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated 40 hours after treatment (P < 0.001) with TG-72 (56.5%) and TG-84 (32.2%) compared with TG-96 and Control-96 (13%) and for all TG treatments 48 hours after treatment (64%) compared with Control-96 (34%, P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96).
Report a problemFND-2488868615
17AnimalAnimal study (in vivo)Efficacy outcome
In sows, OvuGel did not change the wean-to-estrus interval versus untreated control.
In plain wordsIn sows, OvuGel did not change the wean-to-estrus interval versus untreated control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeWean-to-estrus interval versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval did not differ, but the duration of estrus tended (P < 0.10) to be reduced with OvuGel compared with the other treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868622
18AnimalAnimal study (in vivo)Efficacy outcome
In sows, OvuGel did not change the wean-to-estrus interval versus placebo gel.
In plain wordsIn sows, OvuGel did not change the wean-to-estrus interval versus placebo gel.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeWean-to-estrus interval versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval did not differ, but the duration of estrus tended (P < 0.10) to be reduced with OvuGel compared with the other treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868623
19AnimalAnimal study (in vivo)Efficacy outcome
In sows, estrus duration tended to decrease with OvuGel versus untreated control.
In plain wordsIn sows, estrus duration tended to decrease with OvuGel versus untreated control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEstrus duration versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval did not differ, but the duration of estrus tended (P < 0.10) to be reduced with OvuGel compared with the other treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868624
20AnimalAnimal study (in vivo)Efficacy outcome
In sows, estrus duration tended to decrease with OvuGel versus placebo gel.
In plain wordsIn sows, estrus duration tended to decrease with OvuGel versus placebo gel.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEstrus duration versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
Wean-to-estrus interval did not differ, but the duration of estrus tended (P < 0.10) to be reduced with OvuGel compared with the other treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868625
21AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 48 hours was higher with OvuGel (79.1%) than control (46.4%).
In plain wordsIn sows, ovulation by 48 hours was higher with OvuGel than control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after OvuGel treatment (79.1%) compared with Control (46.4%) and Placebo (37.9%) and by 56 hours (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868626
22AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 48 hours was higher with OvuGel (79.1%) than placebo (37.9%).
In plain wordsIn sows, ovulation by 48 hours was higher with OvuGel than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 48 hours versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after OvuGel treatment (79.1%) compared with Control (46.4%) and Placebo (37.9%) and by 56 hours (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868627
23AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 56 hours was higher with OvuGel than control.
In plain wordsIn sows, ovulation by 56 hours was higher with OvuGel than control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 56 hours versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after OvuGel treatment (79.1%) compared with Control (46.4%) and Placebo (37.9%) and by 56 hours (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868628
24AnimalAnimal study (in vivo)Efficacy outcome
In sows, ovulation by 56 hours was higher with OvuGel than placebo.
In plain wordsIn sows, ovulation by 56 hours was higher with OvuGel than placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOvulation by 56 hours versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
More sows ovulated (P < 0.001) by 48 hours after OvuGel treatment (79.1%) compared with Control (46.4%) and Placebo (37.9%) and by 56 hours (P < 0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868629
25AnimalAnimal study (in vivo)Efficacy outcome
In sows, farrowing rate did not differ between OvuGel and control.
In plain wordsIn sows, farrowing rate did not differ between OvuGel and control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFarrowing rate versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and the number of liveborn pigs did not differ among treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868630
26AnimalAnimal study (in vivo)Efficacy outcome
In sows, farrowing rate did not differ between OvuGel and placebo.
In plain wordsIn sows, farrowing rate did not differ between OvuGel and placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFarrowing rate versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and the number of liveborn pigs did not differ among treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868631
27AnimalAnimal study (in vivo)Efficacy outcome
In sows, liveborn pig numbers did not differ between OvuGel and control.
In plain wordsIn sows, liveborn pig numbers did not differ between OvuGel and control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLiveborn pigs versus control, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Untreated control
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and the number of liveborn pigs did not differ among treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868632
28AnimalAnimal study (in vivo)Efficacy outcome
In sows, liveborn pig numbers did not differ between OvuGel and placebo.
In plain wordsIn sows, liveborn pig numbers did not differ between OvuGel and placebo.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLiveborn pigs versus placebo, experiment 3
Study
pign: not reported in source
weaned sows
Comparator
Placebo gel
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
200 μg · intravaginalAs given in this study (pig).
Source sentences
Summary
The farrowing rate and the number of liveborn pigs did not differ among treatments.
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 3, sows (n = 113) were assigned to receive no treatment (Control), intravaginal gel alone (Placebo), or 200 μg of TG given intravaginally (OvuGel) at 96 hours after weaning.
Report a problemFND-2488868633

Studies that did not test the peptide alone5

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

29AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In sows, liveborn pig numbers did not differ across triptorelin timing regimens with single insemination and untreated controls inseminated daily during estrus.
In plain wordsIn sows, liveborn pig numbers did not differ across triptorelin timing regimens with single insemination and untreated controls inseminated daily during estrus.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeLiveborn pigs, experiment 2
Study
pign = 126
weaned sows
Comparator
Control-96 and other timing groups
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The farrowing rate was lower (P 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96). Sows receiving TG were inseminated once 24 to 28 hours after treatment. Control-96 sows were inseminated on each day of standing estrus.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2488868621
30AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In sows, farrowing rate was lower with TG-72 than TG-96.
In plain wordsIn sows, farrowing rate was lower with TG-72 than TG-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFarrowing rate, TG-72 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The farrowing rate was lower (P 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96). Sows receiving TG were inseminated once 24 to 28 hours after treatment. Control-96 sows were inseminated on each day of standing estrus.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2488868617
31AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 72 hours with one insemination produced lower farrowing rates than untreated controls inseminated daily during estrus.
In plain wordsIn sows, triptorelin at 72 hours with one insemination produced lower farrowing rates than untreated controls inseminated daily during estrus.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFarrowing rate, TG-72 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The farrowing rate was lower (P 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96). Sows receiving TG were inseminated once 24 to 28 hours after treatment. Control-96 sows were inseminated on each day of standing estrus.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2488868618
32AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In sows, farrowing rate was lower with TG-84 than TG-96.
In plain wordsIn sows, farrowing rate was lower with TG-84 than TG-96.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFarrowing rate, TG-84 versus TG-96
Study
pign: not reported in source
weaned sows
Comparator
TG-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The farrowing rate was lower (P 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96). Sows receiving TG were inseminated once 24 to 28 hours after treatment. Control-96 sows were inseminated on each day of standing estrus.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2488868619
33AnimalNot a test of Triptorelin (Trelstar, Decapeptyl) aloneAnimal study (in vivo)Efficacy outcome
In sows, triptorelin at 84 hours with one insemination produced lower farrowing rates than untreated controls inseminated daily during estrus.
In plain wordsIn sows, triptorelin at 84 hours with one insemination produced lower farrowing rates than untreated controls inseminated daily during estrus.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFarrowing rate, TG-84 versus control
Study
pign: not reported in source
weaned sows
Comparator
Control-96
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The farrowing rate was lower (P 0.10).
1 context sentence(design, population, supporting numbers)
Summary · context
In experiment 2, sows (n = 126) received 200 μg of TG at 72, 84, or 96 hours after weaning or were untreated (Control-96). Sows receiving TG were inseminated once 24 to 28 hours after treatment. Control-96 sows were inseminated on each day of standing estrus.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-2488868620

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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