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Study · Animal study (in vivo) · rat · 2014

4 results

Postacute effects of kisspeptin-10 on neuronal injury induced by L-methionine in rats.

Akkaya H, Kilic E, Dinc SE, Yilmaz B

Journal of biochemical and molecular toxicology23 May 2014Cited by 19 (Europe PMC)

PMID24863683 (opens in a new tab)DOI10.1002/jbt.21573 (opens in a new tab)PepBankPUB-24863683
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with L-methionine-induced brain injury, kisspeptin treatment reversed the proapoptotic effect of methionine.

    In plain wordsIn rats with brain injury caused by methionine, kisspeptin treatment reversed the increase in cell death.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseApoptotic cell death after methionine
    Study

    ratn: not reported in source

    L-methionine-induced brain injury
    Comparator
    Methionine-treated animals
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    kisspeptin treatment reversed the proapoptotic effect of methionine
    1 context sentence
    Summary · context
    We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats with L-methionine-induced brain injury, kisspeptin treatment was associated with reduced MDA.

    In plain wordsIn rats with brain injury caused by methionine, kisspeptin treatment came with lower levels of the oxidative stress marker MDA.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseMalondialdehyde (MDA) level
    Study

    ratn: not reported in source

    L-methionine-induced brain injury
    Comparator
    Methionine-treated animals
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    reduced MDA
    1 context sentence
    Summary · context
    We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with L-methionine-induced brain injury, kisspeptin treatment was associated with increased glutathione levels.

    In plain wordsIn rats with brain injury caused by methionine, kisspeptin treatment came with higher glutathione levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseReduced glutathione level
    Study

    ratn: not reported in source

    L-methionine-induced brain injury
    Comparator
    Methionine-treated animals
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    increased glutathione levels.
    1 context sentence
    Summary · context
    We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In rats, kisspeptin alone had no side effect on apoptotic cell death.

    In plain wordsIn rats, kisspeptin given alone did not cause more cell death.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeApoptotic cell death with kisspeptin alone
    Study

    ratn: not reported in source

    Rats given kisspeptin-10 alone
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Kisspeptin alone showed no side effect on apoptotic cell death.
    1 context sentence
    Summary · context
    We have investigated the postacute effect of kisspeptin-10 on brain injury induced by L-methionine.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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