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Study · Non-randomized trial · n = 5 · 2014

8 results

Acute and chronic effects of kisspeptin-54 administration on GH, prolactin and TSH secretion in healthy women.

Jayasena CN, Comninos AN, Narayanaswamy S, Bhalla S, Abbara A, Ganiyu-Dada Z, Busbridge M, Ghatei MA, Bloom SR, Dhillo WS

Clinical endocrinology25 Jun 2014Cited by 21 (Europe PMC)

PMID24863252 (opens in a new tab)DOI10.1111/cen.12512 (opens in a new tab)PepBankPUB-24863252
Source linkPubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialOther

    In healthy women, mean serum GH did not change in the first 4 h after kisspeptin‑54 injection compared with vehicle.

    In plain wordsIn healthy women, growth hormone did not change in the first hours after kisspeptin‑54 compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeMean serum GH, first 4 h after injection
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Mean serum GH, PRL and TSH did not change during the first 4 h following kisspeptin-54 injection when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  2. 02HumanNon-randomized trialOther

    In healthy women, mean serum prolactin did not change in the first 4 h after kisspeptin‑54 injection compared with vehicle.

    In plain wordsIn healthy women, prolactin did not change in the first hours after kisspeptin‑54 compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeMean serum prolactin, first 4 h after injection
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Mean serum GH, PRL and TSH did not change during the first 4 h following kisspeptin-54 injection when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  3. 03HumanNon-randomized trialOther

    In healthy women, mean serum TSH did not change in the first 4 h after kisspeptin‑54 injection compared with vehicle.

    In plain wordsIn healthy women, TSH did not change in the first hours after kisspeptin‑54 compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeMean serum TSH, first 4 h after injection
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    Mean serum GH, PRL and TSH did not change during the first 4 h following kisspeptin-54 injection when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  4. 04HumanNon-randomized trialOther

    In healthy women, the mean frequency of GH pulses did not change acutely after kisspeptin‑54 injection compared with vehicle.

    In plain wordsIn healthy women, how often growth hormone pulses occurred did not change after kisspeptin‑54 compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeGH pulse frequency after acute injection
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The mean frequency or amplitude of GH pulses (which influence GH function) did not change acutely following kisspeptin-54 injection when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  5. 05HumanNon-randomized trialOther

    In healthy women, the mean amplitude of GH pulses did not change acutely after kisspeptin‑54 injection compared with vehicle.

    In plain wordsIn healthy women, the size of growth hormone pulses did not change after kisspeptin‑54 compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeGH pulse amplitude after acute injection
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneousAs given in this study (human).

    Source sentences

    Summary
    The mean frequency or amplitude of GH pulses (which influence GH function) did not change acutely following kisspeptin-54 injection when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  6. 06HumanNon-randomized trialOther

    In healthy women, twice-daily kisspeptin‑54 for 7 days caused no chronic change in serum GH compared with vehicle.

    In plain wordsIn healthy women, a week of kisspeptin‑54 injections did not change growth hormone compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeChronic serum GH over 7 days
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneous · 7 daysAs given in this study (human).

    Source sentences

    Summary
    No chronic changes in serum GH, PRL or TSH were observed over the 7-day period of twice-daily kisspeptin-54 injections when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  7. 07HumanNon-randomized trialOther

    In healthy women, twice-daily kisspeptin‑54 for 7 days caused no chronic change in serum prolactin compared with vehicle.

    In plain wordsIn healthy women, a week of kisspeptin‑54 injections did not change prolactin compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeChronic serum prolactin over 7 days
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneous · 7 daysAs given in this study (human).

    Source sentences

    Summary
    No chronic changes in serum GH, PRL or TSH were observed over the 7-day period of twice-daily kisspeptin-54 injections when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).
  8. 08HumanNon-randomized trialOther

    In healthy women, twice-daily kisspeptin‑54 for 7 days caused no chronic change in serum TSH compared with vehicle.

    In plain wordsIn healthy women, a week of kisspeptin‑54 injections did not change TSH compared with vehicle.

    Peptide
    Kisspeptin-54 (metastin)
    Outcome
    No significant changeChronic serum TSH over 7 days
    Study

    n = 5

    Comparator
    Vehicle
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    6·4 nmol/kg twice daily · subcutaneous · 7 daysAs given in this study (human).

    Source sentences

    Summary
    No chronic changes in serum GH, PRL or TSH were observed over the 7-day period of twice-daily kisspeptin-54 injections when compared with vehicle.
    1 context sentence
    Summary · context
    Prospective, single-blinded, placebo-controlled, one-way crossover study. Five healthy women received 7 days of twice-daily subcutaneous bolus vehicle (month 1) or 6·4 nmol/kg kisspeptin-54 (month 2).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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